Results 71 to 80 of about 2,361,676 (390)

Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias [PDF]

, 2010
[Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression of COX-2, EGFR and p53 in 24 ...
Antón-Aparicio, Luis M., Díaz-Prado, Silvia, Luaces Rey, Ramón, López Cedrún, José Luis, Medina Villaamil, Vanessa, Valladares-Ayerbes, Manuel, Álvarez García, Augusto   +6 more
core   +2 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Numerical analysis of the ostiomeatal complex aeration using the CFD method

Scientific Reports, 2023
We aimed to analyse ostiomeatal complex (OMC) aeration using the computational fluid dynamics (CFD) method of simulation based on human craniofacial computed tomography (CT) scans.
Dmitry Tretiakow, Krzysztof Tesch, Karolina Markiet, Tomasz Przewoźny, Aida Kusiak, Dominika Cichońska, Andrzej Skorek   +6 more
doaj   +1 more source

Medium-term culture of normal human oral mucosa: a novel three-dimensional model to study the effectiveness of drugs administration. [PDF]

, 2012
Tissue-engineered oral mucosal equivalents have been developed for in vitro studies for a few years now. However, the usefulness of currently available models is still limited by many factors, mainly the lack of a physiological extracellular matrix (ECM)
Bucchieri, F., Campisi, G., Davies, D., DE CARO, V., Farina, F., Fucarino, A., Giannola, L., Holgate, S., Kudo, Y., Lo Muzio, L., Marcian\uf2, V., MARINO GAMMAZZA, A., Paderni, C., Pitruzzella, A., Siragusa, M., Zummo, G.   +15 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Efficacy of Toluidine Blue—Mediated Antimicrobial Photodynamic Therapy on Candida spp. A Systematic Review

Antibiotics, 2021
The effectiveness of antimicrobial photodynamic therapy (aPDT) in the treatment of oral yeast infections was examined many times in recent years. The authors of this review tried to address the question: “Should TBO (toluidine blue ortho)-mediated aPDT ...
Rafał Wiench, Dariusz Skaba, Jacek Matys, Kinga Grzech-Leśniak   +3 more
doaj   +1 more source

Oral mucosa-on-a-chip to assess layer-specific responses to bacteria and dental materials.

Biomicrofluidics, 2018
The human oral mucosa hosts a diverse microbiome and is exposed to potentially toxic biomaterials from dental restoratives. Mucosal health is partly determined by cell and tissue responses to challenges such as dental materials and pathogenic bacteria ...
Christopher Rahimi, Benjamin Rahimi, Dominic Padova, S. A. Rooholghodos, D. Bienek, Xiaolong Luo, Gili Kaufman, C. Raub   +7 more
semanticscholar   +1 more source

N-alkylamides : from plant to brain [PDF]

, 2014
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart, Joshi, Tanmayee, Taevernier, Lien, Tatke, Pratima, Verbeke, Frederick, Veryser, Lieselotte, Wynendaele, Evelien   +6 more
core  

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Photodynamic therapy in non-surgical treatment of periodontitis

Scientific Reports
Periodontitis is a chronic inflammation disease that, apart from caries, remains the main cause of tooth loss, that lead to a deterioration of the quality of life.
Adrian Maj, Aida Kusiak, Katarzyna Garbacz, Dominika Cichońska, Dariusz Świetlik   +4 more
doaj   +1 more source