Results 91 to 100 of about 56,800 (282)

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura   +4 more
wiley   +1 more source

Sailing in Uncharted Waters: Carefully Navigating the Polio Endgame.

PLoS Medicine, 2016
In a Perspective linked to the research article by Isobel Blake and colleagues, Elizabeth Miller and T. Jacob John discuss the path towards global polio eradication and the challenges, strategies, and necessary precautions around oral polio vaccine ...
Elizabeth Miller, T Jacob John
doaj   +1 more source

Characterization of Household and Community Shedding and Transmission of Oral Polio Vaccine in Mexican Communities With Varying Vaccination Coverage

Clinical Infectious Diseases, 2018
Background The World Health Assembly 2012 Polio Eradication and Endgame Strategic Plan calls for the eventual cessation of all oral polio vaccines (OPVs), to be replaced with inactivated polio vaccine (IPV); however, IPV induces less robust mucosal ...
J. Altamirano, N. Purington, R. Behl, C. Sarnquist, M. Holubar, L. García-García, Leticia Ferreyra-Reyes, Rogelio Montero-Campos, L. Cruz-Hervert, Shanda Boyle, J. Modlin, C. van Hoorebeke, S. Leary, ChunHong Huang, M. Sommer, E. Ferreira-Guerrero, Guadalupe Delgado-Sánchez, Sergio Canizales-Quintero, José L Díaz Ortega, M. Desai, Y. Maldonado   +20 more
semanticscholar   +1 more source

Vaccine coverage and determinants of incomplete vaccination in children aged 12-23 months in dschang, west region, cameroon: a cross-sectional survey during a polio outbreak [PDF]

, 2015
Inadequate immunization coverage with increased risk of vaccine preventable diseases outbreaksremains a problem in Africa. Moreover, different factors contribute to incomplete vaccination status. This study wasperformed in Dschang (West Region, Cameroon),
Biguioh, Rodrigue Mabvouna, Bouting Mayaka, Georges, Miglietta, Alessandro, Pezzotti, Patrizio, Rezza, Giovanni, Russo, Gianluca, Sobze, Martin Sanou, Stefanelli, Paola, Vullo, Vincenzo   +8 more
core   +2 more sources

Effect of Maternal Pregnancy Intention on Neonatal and Infant Healthcare Across the Continuum of Care in Ethiopia: A National Longitudinal Study Using Propensity Score Methods

Child: Care, Health and Development, Volume 51, Issue 5, September 2025.
ABSTRACT Background Completion of the newborn and infant healthcare practices across the continuum of care, including essential newborn care, exclusive breastfeeding from birth to 6 months of age and immunisation, remains low in Ethiopia. Therefore, this study aimed to determine the impact of maternal pregnancy intention on the newborn and infant ...
Birye Dessalegn Mekonnen, Vidanka Vasilevski, Ayele Geleto Bali, Linda Sweet   +3 more
wiley   +1 more source

Plant-made poliovirus vaccines – Safe alternatives for global vaccination

Frontiers in Plant Science, 2022
Human polioviruses are highly infectious viruses that are spread mainly through the fecal-oral route. Infection of the central nervous system frequently results in irreversible paralysis, a disease called poliomyelitis.
Omayra C. Bolaños-Martínez, Richard Strasser   +1 more
doaj   +1 more source

Immunogenicity of New Primary Immunization Schedules With Inactivated Poliovirus Vaccine and Bivalent Oral Polio Vaccine for the Polio Endgame: A Review

Clinical Infectious Diseases, 2018
In May 2016, countries using oral polio vaccine for routine immunization switched from trivalent oral poliovirus vaccine (tOPV) to bivalent type 1 and 3 OPV (bOPV).
A. Bandyopadhyay, J. Modlin, J. Wenger, Chris Gast   +3 more
semanticscholar   +1 more source

An Opportunity Not To Be Missed: Vaccination as an Entry Point for Hygiene Promotion and Diarrhoeal Disease Reduction in Nepal [PDF]

, 2013
This report aims to ascertain whether or not vaccination programmes offer a useful entry point for hygiene promotion and to define options for piloting and scaling up of a hygiene promotion intervention in ...
Katie Greenland, Om Gautam, Yael Velleman   +2 more
core  

From regional pulse vaccination to global disease eradication: insights from a mathematical model of Poliomyelitis [PDF]

, 2014
Mass-vaccination campaigns are an important strategy in the global fight against poliomyelitis and measles. The large-scale logistics required for these mass immunisation campaigns magnifies the need for research into the effectiveness and optimal ...
AJ Terry, AL Lloyd, B Alyward, B Shulgin, Cameron J. Browne, CC Chicone, CJ Browne, DD Bainov, DD Bainov, DD Bainov, DJD Earn, DM Morens, HR Thieme, J Burton, J Liu, JM Heffernan, KR Yameogo, L Bourouiba, LS Liebovitch, Lydia Bourouiba, M Kirkilionis, ME Birmingham, N Bacaer, N Bacaer, N Bacaër, P Driessche van den, PEM Fine, R Breban, Robert J. Smith, S Zipursky, V Lakshmikantham, W Wang, X Meng, X-Q Zhao, Y Xiao, YP Yang, Z Agur   +36 more
core   +2 more sources

Cryomicroneedle Arrays for Biotherapeutics Delivery

Small Science, Volume 5, Issue 8, August 2025.
CryoMNs for biotherapeutic delivery to treat various diseases. CryoMNs: cryomicroneedles. Biotherapy offers a promising approach for treating a variety of diseases. However, the lack of advanced delivery systems remains a significant barrier to improve the efficacy, safety, and cost‐effectiveness of biotherapeutics.
Chunli Yang, Li Zhang, Angxi Zhou, Siyi Wang, Ya Ren, Maya Xiang, Run Tian, Yang Yu, Rong Li, Maling Gou   +9 more
wiley   +1 more source