Results 71 to 80 of about 15,279 (220)

Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative.

PLoS Pathogens, 2015
There are currently huge efforts by the World Health Organization and partners to complete global polio eradication. With the significant decline in poliomyelitis cases due to wild poliovirus in recent years, rare cases related to the use of live ...
Glynis Dunn, Dimitra Klapsa, Thomas Wilton, Lindsay Stone, Philip D Minor, Javier Martin   +5 more
doaj   +1 more source

Role of Serial Polio Seroprevalence Studies in Guiding Implementation of the Polio Eradication Initiative in Kano, Nigeria: 2011-2014. [PDF]

, 2016
BACKGROUND: Nigeria was one of 3 polio-endemic countries before it was de-listed in September 2015 by the World Health Organization, following interruption of transmission of the poliovirus. During 2011-2014, Nigeria conducted serial polio seroprevalence
Abdullahi Walla, Ado J. G. Muhammad, Amina Ahmad-Shehu, Bashir Abba, Centers for Disease Control and Prevention, Harish Verma, Kebba Touray, Kehinde TemilolaOluwa Craig, Marina Takane, Olen, Pascal Mkanda, Peter Nsubuga, Richard Banda, Roland W. Sutter, Rui G. Vaz, Sisay G. Tegegne, Ticha Johnson, World Health Organization, Yared G. Yehualashet, Zubairu Iliyasu   +19 more
core   +1 more source

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

MedComm, Volume 6, Issue 9, September 2025.
NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo, Cong Chen, Wenjing Zhou, Jianqi Hao, Song He, Yu Liu, Yin Ku, Linhua Huang, Chuanfen Zhang, Yueli Shu, Xiaoqing Wu, Yaojia Zhou, Jian Zhang   +12 more
wiley   +1 more source

Circulating Vaccine‐Derived Poliovirus Type 2 (cVDPV2) Outbreak Response With Novel Oral Poliovirus Vaccine Type 2 (nOPV2), Sierra Leone's Experience

Public Health Challenges, Volume 4, Issue 3, September 2025.
ABSTRACT Background In March 2024, a circulating vaccine‐derived poliovirus type 2 (cVDPV2) was isolated in environmental samples (ESs) collected at the Mabella Sawmill Bridge environmental surveillance (ES) site. The Ministry of Health and its partners responded to the outbreak by conducting a novel oral poliovirus vaccine type 2 (nOPV2) nationwide ...
Desmond M. Kangbai, Edwin N. Sesay, Nella Clemens‐Kangbai, Andrew K. Kemoh, Sallu Lansana, Hassan Benya, Aminata Nunie, Joyce M. Kallon, Edna G. Samuels, Amanda Clemens, Michael Jones, Braima Patrick Kanneh, Peter B. James, Andrew Alfred Nyakeh Jimmy, Mohamed T. M. Kallay, Tom Sesay   +15 more
wiley   +1 more source

Research Progress Towards Poliovirus Virus-like Particle Vaccines: A Review

Vaccines
Poliovirus (PV), a historically significant enterovirus responsible for severe paralytic diseases, has seen its incidence dramatically reduced through widespread vaccination efforts, propelling global eradication initiatives.
Taoli Han, Jinbo Xiao, Shiyao Zhang, Tongyue Su, Yinuo Liu, Yong Zhang   +5 more
doaj   +1 more source

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura   +4 more
wiley   +1 more source

Vaccine-Derived Poliovirus Infection among Patients with Primary Immunodeficiency and Effect of Patient Screening on Disease Outcomes, Iran

Emerging Infectious Diseases, 2019
Patients with immunodeficiency-associated vaccine-derived poliovirus (iVDPV) are potential poliovirus reservoirs in the posteradication era that might reintroduce polioviruses into the community.
Mohammadreza Shaghaghi, Shohreh Shahmahmoodi, Ali Nili, Hassan Abolhassani, Seyedeh Panid Madani, Ahmad Nejati, Maryam Yousefi, Yaghoob M. Kandelousi, Mona Irannejad, Shiva Shaghaghi, Seyed Mohsen Zahraei, Sussan Mahmoudi, Mohammad Mehdi Gouya, Reza Yazdani, Gholamreza Azizi, Nima Parvaneh, Asghar Aghamohammadi   +16 more
doaj   +1 more source

OPV strains circulation in HIV infected infants after National Immunisation Days in Bangui, Central African Republic [PDF]

, 2010
Background Humans are the only host of polioviruses, thus the prospects of global polio eradication look reasonable. However, individuals with immunodeficiencies were shown to excrete vaccine derived poliovirus for long periods of time which led to ...
Alexandre Manirakiza, Emmanuella Picard, Richard Ngbale, Didier Menard, Ionela Gouandjika-Vasilache, JP Alexander Jr, WR Dowdle, OM Kew, DN Pavlov, DN Pavlov, M Fernandez-Ibieta, MC Tejiokem, PNUD, I Gouandjika-Vasilache, KA Hennessey, JV Giorgi, D Menard, WHO, DJ Wood, S Guillot, J Balanant, JD Thompson, W Borkowsky, FP Kroon, RW Ryder, WJ Moss, NA Halsey   +26 more
core   +3 more sources

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions

The FEBS Journal, Volume 292, Issue 6, Page 1480-1499, March 2025.
Vaccination plays a crucial role in mediating protection against infectious diseases, but immune responses to vaccination are highly variable and frequently sub‐optimal in vulnerable populations. Here, we review the latest preclinical and clinical evidence demonstrating that the gut microbiota plays a significant role in regulating immune responses to ...
Charné Rossouw, Feargal J. Ryan, David J. Lynn   +2 more
wiley   +1 more source