Results 51 to 60 of about 15,279 (220)

Tuberculosis and gender: exploring the patterns in a case control study in Malawi. [PDF]

, 2004
BACKGROUND: In many populations there is an excess of tuberculosis in young women and older men. We explored possible explanations for these patterns, concentrating on human immunodeficiency virus (HIV) status, pregnancy, smoking, cooking smoke exposure,
Crampin, AC, Fine, PEM, Floyd, S, Glynn, JR, Malema, SS, Mwaungulu, FD, Mwinuka, VK, Ngwira, BMM, Warndorff, DK   +8 more
core  

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Development of Thermostable Lyophilized Sabin Inactivated Poliovirus Vaccine

mBio, 2018
As oral poliovirus vaccine (OPV) causes vaccine-associated paralytic poliomyelitis, the polio endgame strategy introduced by the Global Polio Eradication Initiative calls for a phased withdrawal of OPV and an introduction of inactivated poliovirus ...
Woo-Jin Shin, Daiki Hara, Francisca Gbormittah, Hana Chang, Byeong S. Chang, Jae U. Jung   +5 more
doaj   +1 more source

Sabin polio virus protein 1 (VP1) evolution in patients with acute flaccid paralysis from 2010 to 2016 in Uganda

Virology Journal, 2023
Acute flaccid paralysis (AFP) is a rare side effect of the oral polio vaccine but can be associated with outbreaks and permanent disability in patients harboring circulating vaccine-derived polioviruses (cVDPVs).
Mary Bridget Nanteza, Barnabas Bakamutumaho, Phionah Tushabe, Prossy Namuwulya, Molly Birungi, Rajab Dhatemwa, James Peter Eliku, Mayi Tibanagwa, Proscovia Kakooza, Henry Bukenya, Josephine Bwogi, Charles Rutebarika Byabamazima   +11 more
doaj   +1 more source

Has wild poliovirus been eliminated from Nigeria?

, 2015
Wild poliovirus type 3 (WPV3) has not been seen anywhere since the last case of WPV3-associated paralysis in Nigeria in November 2012. At the time of writing, the most recent case of wild poliovirus type 1 (WPV1) in Nigeria occurred in July 2014, and ...
Famulare, Michael
core   +3 more sources

Next‐Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Immunotherapy has reshaped the oncology landscape by enabling the immune system to recognize and eliminate malignant cells. Although immune checkpoint inhibitors (ICIs) targeting cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4), programmed cell death‐1 (PD‐1), and programmed death‐ligand 1 (PD‐L1) have achieved durable responses in several cancers,
Jhommara Bautista, Carolina E. Echeverría, Iván Maldonado-Noboa, Joseth Adatty-Molina, Salomé Suárez Urresta, Emily C. Coral-Riofrio, Salomé Araujo-Abad, Nikolaos C. Kyriakidis, Andrés López-Cortés, Poorani Gurumallesh Prabu   +9 more
wiley   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Poliovirus shedding after sequential immunization of Sabin-strain inactivated polio vaccines and oral attenuated polio vaccines

npj Vaccines
The identification of poliovirus in stool samples post-Oral Poliovirus Vaccine (OPV) immunization is essential for implementing post-eradication monitoring of poliomyelitis.
Yuting Fu, Rufei Ma, Zhimei Zhao, Zhaojun Mo, Zhifang Ying, Jing Li, Hui Ye, Guoliang Li, Xiaochang Liu, Jiangli Liang, Ling Ping, Jingyan Li, Junhui Tao, Qinghai Yang, Dingkai Wei, Li Yi, Hongbo Chen, Jianfeng Wang, Ruiju Jiang, Lei Yu, Wei Cai, Wei Yang, Lei Yue, Mingxue Xie, Qiongzhou Yin, Jing Pu, Chao Hong, Lukui Cai, Yan Deng, Jiana Wen, Yan Ma, Na Gao, Xiaoyu Wang, Hongwei Liao, Qiuyan Ji, Guang Ji, Wenzhu Hu, Qin Gu, Xiaoyue He, Han Chu, Yixian Fu, Jian Zhou, Yu Wen, Xiaolei Yang, Changgui Li, Li Shi, Ting Zhao, Teng Huang, Jingsi Yang   +48 more
doaj   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source

A Pseudovirus‐Based Method for the Simultaneous Quantitation of Neutralization Antibodies Against All Three Poliovirus Serotypes

MedComm, Volume 6, Issue 12, December 2025.
By optimizing P1 expression, sensitive cell selection, and plasmid transfection ratios, we produced a high‐titer poliovirus pseudovirus. Based on high‐titer pseudovirus encoding distinct fluorophores (E2, eGFP, and RFP), we developed a tri‐color pseudovirus‐based neutralization assay (PBNA) for the simultaneous quantification of neutralizing antibodies
Meiyan Liu, Yuanling Yu, Yadong Li, Zexin Tao, Lan Huang, Xi Wu, Yong Zhang, Shuangli Zhu, Qiang Sun, Tianjiao Ji, Dongyan Wang, Ziteng Liang, Shuo Liu, Meina Cai, Yimeng An, Jierui Li, Weijin Huang, Guoyang Liao, Li Yi, Lei Ma, Li Zhang, Youchun Wang   +21 more
wiley   +1 more source