Results 91 to 100 of about 103,250 (300)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

Neurocognitive impairment is associated with lower health literacy among persons living with HIV infection. [PDF]

open access: yes, 2014
This study sought to determine the effects of HIV-associated neurocognitive disorders (HAND) on health literacy, which encompasses the ability to access, understand, appraise, and apply health-related information.
Blackstone, Kaitlin   +6 more
core   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

open access: yesAdvanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander   +14 more
wiley   +1 more source

Reading Fluency and the Role of Its Dimensions

open access: yesCanadian Journal for New Scholars in Education, 2021
Based on a review of existing research, this paper aims to provide an overview of reading fluency and its dimensions. We examine the term “fluency” which was first introduced to denote automatic word recognition in 1970s, and then extended to include ...
Ling Li, Antoinette Doyle
doaj  

Intensive Summer Intervention Drives Linear Growth of Reading Skill in Struggling Readers

open access: yesFrontiers in Psychology, 2019
A major achievement of reading research has been the development of effective intervention programs for struggling readers. Most intervention studies employ a pre-post design, to examine efficacy, but this precludes the study of growth curves over the ...
Patrick M. Donnelly   +5 more
doaj   +1 more source

Differences in the Components and Relations of a Multidimensional Model of Reading Comprehension in Low and Average 8- to 11-Year-Old French Readers.

open access: yes, 2014
International audienceIf the simple view of reading earlier characterised reading comprehension as a product of decoding and linguistic comprehension, research has evolved to a more complex simple view including speed or fluency as a major factor of ...
Bianco, Maryse   +5 more
core   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang   +11 more
wiley   +1 more source

Eye movements in oral reading by primary school students: The relevance of punctuation marks

open access: yesKáñina
This study aims to explore the relevance of punctuation marks during oral reading. To achieve this objective, we compared eye movement metrics of two groups of 5th-year students, classified based on the Reading Fluency variable. The fluent reading group
Nair Daiane de Souza Sauaia Vansiler   +2 more
doaj   +1 more source

Measuring beginner reading skills: An empirical evaluation of alternative instruments and their potential use for policymaking and accountability in Peru [PDF]

open access: yes
Based on analysis of reading performance data from 475 third-graders in Peru, this study makes recommendations on improving reading tests, choice of reading standards, and how to present the results at the school and individual levels.
Bazan, Jorge, Kudo, Ines
core  

Responsive socio-cultural contexts: Supporting five year olds to become literate in a second language. [PDF]

open access: yes, 2012
Learning one's own indigenous language and culture as a second language learner within formal mainstream education settings can pose many challenges, especially for students who have been raised in the dominant first language and who are just beginning ...
Berryman, Mere   +2 more
core   +2 more sources

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