Results 91 to 100 of about 3,898,040 (219)

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

ORAL REHYDRATION SOLUTION (ORS) SEBAGAI TERAPI PADA PASIEN DENGAN VOMITUS PROFUSE DISERTAI DADS [PDF]

, 2018
Latar belakang :. Dehidrasi adalah suatu keaadaan penurunan total air di dalam tubuh karena hilangnya cairan secara patologis, asupan air tidak adekuat, atau kombinasi keduanya.
SARI, TRIA EVITA
core   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Oral rehydration points (ORPs ): planning and guidance [PDF]

A comprehensive strategy for cholera treatment includes not only establishment of Cholera Treatment Centers (CTCs) and Cholera Treatment Units (CTUs) but also support of community services to provide early rehydration when distance, safety, or other ...

core   +1 more source

Prevalence and predictors of oral rehydration therapy, zinc, and other treatments for diarrhoea among children under-five in sub-Saharan Africa. [PDF]

PLoS One, 2022
Ahinkorah BO, Aboagye RG, Seidu AA, Frimpong JB, Cadri A, Afaya A, Hagan JE, Yaya S.   +7 more
europepmc   +1 more source

Oral rehydration therapy [PDF]

Archives of Disease in Childhood, 2001
M K, Davies, A J, Mayne
openaire   +2 more sources

c‐MET Inhibition Is Accompanied by PD‐L1 Upregulation and Immunosuppression‐Related Tumor Microenvironment Changes in Esophageal Squamous Cell Carcinoma, With Enhanced Antitumor Activity in Combination With Anti‐PD‐1 Therapy

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background c‐MET is implicated in ESCC progression, but whether c‐MET inhibition reshapes immune checkpoint expression and the tumor immune microenvironment remains unclear. Methods ESCC cell lines were treated with Tepotinib, and c‐MET and PD‐L1 expression were examined by Western blotting and immunofluorescence.
Chuan Song, Zhe Xia, Hu Wang, Xinyu Wang, Jing Li, Binbin Wang, Chen Feng, Bo Xie   +7 more
wiley   +1 more source

Correction: Nalin, D. Issues and Controversies in the Evolution of Oral Rehydration Therapy (ORT). Trop. Med. Infect. Dis. 2021, 6, 34. [PDF]

Trop Med Infect Dis, 2022
Nalin D.
europepmc   +1 more source

Symmetrical Peripheral Gangrene in a Child With Plasmodium falciparum Cerebral Malaria: A Rare but Serious Complication

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Symmetrical peripheral gangrene is a rare, limb‐threatening complication associated with severe infection and disseminated intravascular coagulation. We report a case of a 6‐year‐old girl with cerebral malaria who developed gangrene of all toes during treatment.
Ebenezer Ahenkan, Maame Fremah Kotoh‐Mortty, Felix Osei Boateng, Kwabena Karikari Donkor, Nicole Sunaina Struck, Jürgen May, Oumou Maiga Ascofare   +6 more
wiley   +1 more source

Current trends in the management of childhood gastroenteritis in the community [PDF]

, 1989
Infection of the gastrointestinal tract are still amongst the most common infections of childhood. Despite improvements in the standard of living over the last fifty years, gastroenteritis still constitutes a sizeable amount of general practitioner ...
Vella, Cecil
core