Results 31 to 40 of about 3,898,040 (219)

Cost-effectiveness analysis of oral rehydration therapy compared to intravenous rehydration for acute gastroenteritis without severe dehydration treatment

Journal of Infection and Public Health, 2019
Background: Diarrhea causes, annually, approximately 1.7 billion cases and 760,000 deaths worldwide among children under 5 years of age, although these are preventable and treatable.
Gabriela G. Mosegui, Cid M. Vianna, Marcus S. Rodrigues, Paula M. Valle, Frances V. Silva   +4 more
doaj   +1 more source

Meta-graph comparing oral rehydration therapy vs. intravenous fluid therapy.

, 2015
Results from meta-analysis of direct comparisons of oral rehydration therapy vs. intravenous fluid therapy on the outcomes of admission to hospital from the emergency department and revisits to the emergency departments, displayed employing Forest plots.
Eleanor Fitzpatrick (755033), Stephen B. Freedman (239931), Karen J. L. Black (755032), Serge Gouin (755034), Lisa Hartling (3643), Andrea Milne (755035), Dion Pasichnyk (755031)   +6 more
core   +1 more source

Hidratación oral con una solución de baja osmolaridad en niños deshidratados por enfermedades diarreicas: un estudio clínico controlado.

Biomédica: revista del Instituto Nacional de Salud, 2003
Se realizó un estudio clínico controlado para comparar la efectividad de un suero de baja osmolaridad (SBO) (245 mOsm/L), en relación con la solución de hidratación oral estándar recomendada por la OMS (SHO/OMS). El grupo 1 (69 niños) recibió el suero de
Carlos Bernal, Claudia Velásquez, Guillermo García, Gustavo Uribe, Carlos Mauricio Palacio   +4 more
doaj   +1 more source

Effectiveness of Ondansetron in comparison to Domperidone for treating vomiting in acute gastroenteritis among children in a tertiary care hospital setting: A quasi-experimental study

Journal of University Medical & Dental College, 2023
BACKGROUND & OBJECTIVE: There is inconsistent evidence on using antiemetic drugs (ondansetron and domperidone) in children with vomiting associated with gastroenteritis having dehydration.
Muddassir Zafar, Wajiha Rizwan, Muhammad Rafique, Shahid Mahmood , Yasir Javed   +4 more
doaj   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Oral rehydration solutions in watery diarrhea in children: what’s new?

Медицинский совет, 2020
Acute infectious diarrhoea is still a topical problem in pediatrics today. Approximately 95% of children under five years of age suffer from acute intestinal infection at least once or several times.
I. N. Zakharova, I. V. Berezhnaya, A. T. Kamilova, O. V. Dedikova   +3 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Severe Diarrhea in a 4-Month-Old Baby Girl with Acute Gastroenteritis: A Case Report and Review of the Literature

Case Reports in Gastrointestinal Medicine, 2012
A 4.5-month-old baby girl presented to hospital with a 2-day history of watery diarrhea and fever. Rehydration and electrolytic balance were restored with intravenous fluid therapy followed by oral rehydration solution but diarrhea did not improve by the
Ionela Loredana Guzganu
doaj   +1 more source

Cyclic Vomiting Syndrome in Children

Zdorovʹe Rebenka, 2016
Introduction. Cyclic vomiting syndrome (CVS) — is a fairly common disease of unknown etiology that affects children of all age groups and sometimes adult population and refers to the functional disorders of the gastrointestinal tract.
T.V. Sorokman, S.V. Sokolnyk, O.-M.V. Popelyuk, L.V. Shvygar   +3 more
doaj   +1 more source