Results 61 to 70 of about 5,586,070 (250)

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms

, 2022
S.2735-2745Parameterization of dissolution profiles for subsequent use in in silico modeling and simulation is a crucial element for the success of extrapolating in vitro to in vivo release from solid oral dosage forms.
Hofsäss, M.A., Dressman, J.
core   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Oral Solid Dosage Forms

Oral drug delivery remains the most popular and convenient way of administering drugs in comparison with the other routes. Advantages include their effectiveness, convenience, less expensive, and non-invasiveness.
Muhamad, Haja, Asare-Addo, Kofi, Totea, Ana‑Maria, Rowland, Martin, Adebisi, Adeola; id_orcid   +4 more
core   +1 more source

Caracterização e estudos das propriedades no estado sólido do cloridrato de venlafaxina [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2013.O cloridrato de venlafaxina (VEN) é um inibidor da recaptação da serotonina e norepinefrina eficaz no ...
Bernardi, Larissa Sakis
core  

3D printing of lipid-based formulations into personalized solid oral dosage forms [Elektronisk resurs]

, 2023
The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all.
Paulsson, Mattias,, Johannesson, Jenny,, Bergström, Christel,, Teleki, Alexandra,, Strömme, Maria,, Basit, Abdul,   +5 more
core  

Biowaiver monographs for immediate release solid oral dosage forms: Aciclovir [PDF]

, 2008
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing (biowaiver) for the approval of immediate release (IR) solid oral dosage forms containing aciclovir are reviewed.
Arnal, J., Bermejo, M., Barends, D. M., Midha, Kamal K., Shah, V. P., Dressman, Jennifer B., Junginger, H. E., Amidon, Gordon L., Stavchansky, S., Kopp, S., Gonzalez-Alvarez, I.   +10 more
core   +1 more source

The potential of three-dimensional printing for pediatric oral solid dosage forms

Acta Pharmaceutica
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid ...
Kreft Klemen, Fanous Marina, Möckel Volker   +2 more
doaj   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

An alternative approach to adjustment of the level of incorporation of boundary lubricants to accommodate changes in granule or blend characteristics

Journal of Excipients and Food Chemicals, 2016
A method is proposed whereby the determination of the level of incorporation of a boundary lubricant is based on the surface area of the blend or granulation and the shape of the lubricant particles.
R. Christian Moreton
doaj