Results 91 to 100 of about 214,541 (306)

Diagnostic Value of Serum and Saliva Matrix Metalloproteinase13 (MMP13) in Oral Squamous Cell Carcinoma

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2020
BACKGROUND AND OBJECTIVE: Matrix metalloproteinases (MMPs) are a group of enzymes responsible for extracellular matrix breakdown. Increased activity of type 13 is involved in invasion of oral squamous cell carcinoma.
T Ghanbarnia, M Seyedmajidi, M Mehryari, A Bijani, M Pooramir, R Foroughi   +5 more
doaj  

A randomized, phase II study of afatinib versus cetuximab in metastatic or recurrent squamous cell carcinoma of the head and neck. [PDF]

, 2014
BackgroundAfatinib is an oral, irreversible ErbB family blocker that has shown activity in epidermal growth factor receptor (EGFR)-mutated lung cancer.
Blackman, A, Clement, PM, Cohen, EEW, Cupissol, D, Degardin, M, Del Campo, JM, Ehrnrooth, E, Fayette, J, Hitt, R, Seiwert, TY, Zhang, W   +10 more
core   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Oral Squamous Cell Carcinoma [PDF]

, 2012
Brent B. Ward, Fayette C. Williams
  +5 more sources

FBXW7 expression affects the response to chemoradiotherapy and overall survival among patients with oral squamous cell carcinoma: A single-center retrospective study

Tumor Biology, 2017
FBXW7 (F-box and WD repeat domain containing-7) is a tumor suppressor protein that regulates the degradation of various oncoproteins in several malignancies.
Hidetaka Arita, Masashi Nagata, Ryoji Yoshida, Yuichiro Matsuoka, Akiyuki Hirosue, Kenta Kawahara, Junki Sakata, Hikaru Nakashima, Taku Kojima, Ryo Toya, Ryuji Murakami, Akimitsu Hiraki, Masanori Shinohara, Hideki Nakayama   +13 more
doaj   +1 more source

A new concurrent chemotherapy with vinorelbine and mitomycin C in combination with radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck [PDF]

, 2005
Objective: The purpose of this pilot study was to evaluate the feasibility and toxicity of concurrent chemotherapy with vinorelbine and mitomycin C in combination with accelerated radiotherapy (RT) in patients with locally advanced cancer of the head and
Bernier J, Budach W, Colevas AD, Colleoni M, Conti F, De Placido S, Degardin M, Dische S, Dobrowsky W, Gasparini G, Gralla R, Grau C, Haffty BG, Harrison LB, Hehr T, Kies MS, Koch WM, Munker R, Pouillart P, Poulsen MG, Regine WF, Shin DM, Siu LL, Vici P, Vokes EE, Wendt TG   +25 more
core   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment. [PDF]

, 2011
BACKGROUND: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer.
Bessell, A, Clarkson, JE, Conway, DI, Furness, S, Glenny, A-M, Macluskey, M, Oliver, R, Pavitt, S, Sloan, P, Worthington, HV   +9 more
core   +3 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Corellation of p53 expressions and histopathological grading in oral cavity squamous cell carcinoma

Dental Journal, 2016
Background: Squamous cell carcinoma is a malignancy of oral cavity mostly occurred and can also metastasize. p53 gene is a tumor suppressor gene that plays an important role in carcinogenesis.
Silvi Kintawati
doaj   +1 more source