Results 21 to 30 of about 124,134 (216)

Association of Porphyromonas gingivalis-infected oral squamous cell carcinoma cell-secreted exosomal miR-3648-1-p5 with tumor progression

Cancer Cell International
Background Oral squamous cell carcinoma accounts for over 90% of oral malignancies and remains a major global public health concern. Our previous study identified Porphyromonas gingivalis (P.
Xiaorong Tan, Zhangping Tan, Wenyue Xu, Yuchuan Zhou, Wei Wei, Chenxi Li, Muqiu Li, Zhongcheng Gong   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Epidemiology and incidence of oral squamous cell carcinoma in the Iraqi population over 5 years (2014–2018)

Health Science Reports, 2023
Background Oral squamous cell carcinoma is one of the most common and life‐threatening neoplasms worldwide, and is responsible for approximately 90% of all oral malignancies. Aim This study was aimed at providing updated information on oral squamous cell
Muhanad L. Alshami, Mohammed Abbood Al‐Maliky, Ali Arkan Alsagban, Ali J. Alshaeli   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Correlation of E-cadherin, vimentin, CD206, programmed cell death receptor 1, and programmed cell death ligand 1 expressions with clinicopathological factors and prognosis in oral squamous cell carcinoma

Journal of International Medical Research
Objective Oral squamous cell carcinoma is the most common malignant tumor occurring in the head and neck region. Current treatment principles are based on radical surgery, supplemented by radiotherapy and chemotherapy.
Zheng-Yi Lai, Jie Ma, Jia-Yi Yin, Xiu-An Zhu, Jing-Ping Zhou, De-Tao Tao   +5 more
doaj   +1 more source

E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma

Journal of Oral Biology and Craniofacial Research
Background: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation.
Dhanusree Kani, Vindhya Savithri, Rakesh Suresh, Ramanarayanan Venkitachalam, Mahija Janardhanan, Thara Aravind   +5 more
doaj   +1 more source

Rapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma

Tumor Biology, 2017
YM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation.
Kong-Liang Li, Yu-Fan Wang, Jia-Ruo Qin, Feng Wang, Yong-Tao Yang, Li-Wu Zheng, Ming-Hua Li, Jie Kong, Wei Zhang, Hong-Yu Yang   +9 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

seed lectin inhibits oral squamous cell carcinoma tumorigenesis by suppressing N6-methyladenosine modification–mediated SRY-box transcription factor 2 expression

Journal of International Medical Research
Objective Studies have indicated that combining Maackia amurensis seed lectin with first-line chemotherapeutic agents enhances the efficacy of treatment for oral squamous cell carcinoma.
Yong Du, Haiyan Yang, Hongguang Lian, Dan Li, Weina Liu, Linyuan Zhao, Yufeng Zhang   +6 more
doaj   +1 more source