Results 291 to 300 of about 257,176 (353)

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

open access: yesThe FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt   +5 more
wiley   +1 more source

Plant‐produced encapsulin displays non‐typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles

open access: yesThe FEBS Journal, EarlyView.
This study investigates the potential of encapsulin as an antigen display platform for the development of a candidate Salmonella vaccine for poultry. Encapsulin constructs were transiently expressed in Nicotiana benthamiana where they accumulated to high levels.
Carly A. Charron   +6 more
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

open access: yesThe FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris   +2 more
wiley   +1 more source

Efficacy and safety of rimegepant for the acute treatment of migraine in Black or African American adults: A post hoc pooled subgroup analysis from three randomized, placebo‐controlled clinical trials

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This post hoc subgroup analysis was conducted using pooled data from three US‐based clinical trials to compare efficacy and safety of rimegepant 75 mg versus placebo in acute migraine in adults who are Black or African American.
Larry Charleston IV   +6 more
wiley   +1 more source

Effect of land use change on Melolonthidae (Coleoptera: Scarabaeoidea) beetle communities in the deforestation arc of the Brazilian Amazon

open access: yesInsect Conservation and Diversity, EarlyView.
Habitat transformation in Amazon due to agriculture expansion impairs Melolonthidae diversity. Assemblage response towards habitat transformation are group‐dependent. Although highly disturbed, Amazon arc of deforestation region dwells sensitive insect assemblages. Abstract Although the Amazon provides crucial goods and ecosystem services for humanity,
Kleyton Rezende Ferreira   +4 more
wiley   +1 more source
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Oral Shigella Vaccines

1989
Shigellae cause intestinal disease by invading the colonic epithelium. Intracellular multiplication and intercellular spread of these organisms results in mucosal lesions and inflammation of the lamina propria (LaBrec et al. 1964). These lesions are usually confined to the colon, and they are responsible for the bloody, mucoid stools characteristic of ...
T L, Hale, S B, Formal
openaire   +2 more sources

Oral vaccine in otosclerosis

Medical Hypotheses, 2000
Otosclerosis is a genetically based disease in which the development of autoimmune mechanisms can lead to its clinical expression. Anti-type II collagen antibodies have been found in otosclerotic patient serum. The first clinically unexpressive phase of the disease can be diagnosed from a family history and ON-OFF stapedial reflexes with evidence of an
M A, Lopez-Gonzalez, F, Delgado
openaire   +2 more sources

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