Results 51 to 60 of about 70,520 (259)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Iconarp International Journal of Architecture and Planning, 2021 Purpose Colourful street furniture, fitness and playground equipment has become increasingly common in contemporary urban green spaces. The study aims to increase knowledge about their influence on human perception of urban park settings, and explore ...
Petra Thorpert, Jan-Eric Englund
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The Association Between the Flesh Colour and Carotenoid Profile of 25 Cultivars of Mangoes
MoleculesMango (Mangifera indica L.) cultivars display a wide range of ripe flesh colours, from deep-orange to pale-yellow, largely linked to differences in carotenoid profiles.
Tatsuyoshi Takagi +5 more
doaj +1 more source
Comparative Investigation of Red and Orange Roman Tesserae: Role of Cu and Pb in Colour Formation
Heritage, 2022 This study aims at the characterisation of red and orange glass tesserae from the 4th-century Roman villa of Noheda (Spain). Due to the limited number of analyses available for such ancient materials, many questions remain unanswered about the production
Cécile Noirot +5 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Tropical Zoology, 2017 Finlayson’s squirrel, Callosciurus finlaysonii, is distributed in lowland forests throughout South-East Asia. Its pelage colour is conspicuous and polymorphic (red, black, white and a mixture of these colours), which is characteristic of the species ...
Noriko Tamura +4 more
doaj
Gamma ray Induced Light-orange Flower Mutant in Groundnut (Arachis hypogaea L.) and its inheritance [PDF]
Electronic Journal of Plant Breeding, 2012 A dwarf mutant plant having small leaves and light-orange flower was identified in the M2 generation from gammaray treated groundnut cultivar VRI 2. The mutant bred true in successive generations.
A. Mothilal* and M. Jayaramachandran
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source