Results 61 to 70 of about 32,965 (298)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

INVENTORY MODEL FOR ORANGE SUPPLIERS IN LEMBANG SUBDISTRICT OF WEST BANDUNG REGENCY, INDONESIA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
Inventory is the act of storing raw materials, semi-finished goods, or finished products with the aim of optimizing the smoothness of production processes or business operations within a company, whether in the manufacturing or service sector.
Arifianti R., Taryana A., Pamungkas M.R.
doaj   +1 more source

Kebaikan Orang-Orang Kafir

Al-Kauniyah, 2022
Penelitian ini dilatar belakangi oleh perdebatan klise setiap tahunnya antara umat muslim dan nasrani, yaitu hari raya Natal. Perdebatan tentang mengucapkan selamat Natal yang terus-menerus mengalir menjadikan nya semakin merembet menuju celah-celah permasalahan lain, hingga pada puncaknya, bermuara pada surga dan neraka. Narasi “yang penting baik sama
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparative Analysis of Foot Sole Classification Models: Evaluating Logistic Regression, SVM, and Random Forest

Journal of Applied Informatics and Computing
Accurate sole classification and types can aid applications in healthcare, sports, and biometrics such as diagnosis of high arch or flat foot disease, as well as in improved design of custom orthotics and enhanced gait analysis to improve sports ...
Trie Dinda Maharani Purba, Imam Yuadi
doaj   +1 more source

AN ASSESSMENT FOR EGYPT’S ORANGES EXPORTS IN INTERNATIONAL MARKETS تقييم صادارات البرتقال المصرى فى الأسواق العالمية [PDF]

Journal of Agricultural Economics and Social Sciences, 2014
The study aims to investigate the performance and potentiality of Egypt’s oranges exports in international markets throughout the last two decades.
أحمد الخولى
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Five Oranges, Four Apples [PDF]

, 1957
Woman picking apples and oranges from treehttps://scholarsjunction.msstate.edu/cht-sheet-music/11791/thumbnail ...
Curtis, Mann
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source