Results 41 to 50 of about 1,508 (215)

ESTUDO DA ORIENTAÇÃO DE LARANJAS IMERSAS EM ÁGUA

Revista Brasileira de Engenharia Agrícola e Ambiental
RESUMO À medida que o custo de métodos tradicionais de transporte mecânico ou manual aumenta, existe a possibilidade de que o transporte hidráulico de laranjas em canais, como já é empregado em algumas indústrias nacionais, se torne economicamente ...
Maria Elita Duarte Braga, Carlos Alberto Gasparetto   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

The Orange as an Orange

Jama'a: an Interdisciplinary Journal of Middle East Studies
يقترح هذا المقال محو اًرً للتطوّّر في شعريّّة النثر العربيّّ بعد أزمة 1967 ، ويضعه في مقارنة مع التحوّّلات الجماليّّة التي شهدتها الرواية خلال تلك الفترة. ففي حين اتّّجهت الرواية نحو الانفصال عن الواقعيّّة، اتّّجه العديد من شعراء النثر البارزين في اتّلاّجاه المعاكس، نحو الواقعيّّة الغنائيّّة وشعريّّة التفاصيل اليوميّّة.
openaire   +1 more source

Kebaikan Orang-Orang Kafir

Al-Kauniyah, 2022
Penelitian ini dilatar belakangi oleh perdebatan klise setiap tahunnya antara umat muslim dan nasrani, yaitu hari raya Natal. Perdebatan tentang mengucapkan selamat Natal yang terus-menerus mengalir menjadikan nya semakin merembet menuju celah-celah permasalahan lain, hingga pada puncaknya, bermuara pada surga dan neraka. Narasi “yang penting baik sama
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

INVENTORY MODEL FOR ORANGE SUPPLIERS IN LEMBANG SUBDISTRICT OF WEST BANDUNG REGENCY, INDONESIA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
Inventory is the act of storing raw materials, semi-finished goods, or finished products with the aim of optimizing the smoothness of production processes or business operations within a company, whether in the manufacturing or service sector.
Arifianti R., Taryana A., Pamungkas M.R.
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Comparative Analysis of Foot Sole Classification Models: Evaluating Logistic Regression, SVM, and Random Forest

Journal of Applied Informatics and Computing
Accurate sole classification and types can aid applications in healthcare, sports, and biometrics such as diagnosis of high arch or flat foot disease, as well as in improved design of custom orthotics and enhanced gait analysis to improve sports ...
Trie Dinda Maharani Purba, Imam Yuadi
doaj   +1 more source