Results 71 to 80 of about 17,614 (267)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Analysis of factors affecting dominant acoustic impulse-response frequency of orange fruit based on grey relative theory

浙江大学学报. 农业与生命科学版, 2005
Using nondestructive acoustic impulse-response technique to evaluate the quality of oranges, it was found that there were lots of factors affecting dominant impulse-response frequency, such as mass, density, pH value, firmness and sugar content ...
HUANG Hui-ming, WANG Jun, HU Gui-xian, LU Qiu-jun, LUO Jian-yi   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Are Pesticide Residues Found in the Oranges Produced in Sari? [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: Today, ensuring food security for the inhabitants of the earth, and preserving agricultural production from destruction due to drought, pests, and diseases, seems more necessary than ever.
Narges Mazloomi, Ebrahim Salehifar, Mohammadhosein Esfahanizadeh, Hashem Ghezelsofla, Keyvan Mahdavi Mashaki, Esmaeil Babanezhad, Laleh Karimzadeh   +6 more
doaj  

PENERAPAN REKAYASA MESIN SORTIR SEBAGAI PENENTU KEMATANGAN BUAH JERUK DAN TOMAT MERAH BERBASIS IMAGE PROCESSING

Jurnal Teknik Pertanian Lampung, 2020
The embedded systems in the industrial, especially image processing, is increasingly leading to the study of production automation systems such as fruit sorting.
Ridwan Siskandar, Noer. A. Indrawan, Billi Rifa Kusumah, Sesar Husen Santosa, Irmansyah, Irzaman   +5 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Comparison postharvest quality of conventionally and organically grown ‘Washington Navel’ oranges

Journal of Applied Botany and Food Quality, 2013
This study aimed to compare postharvest quality of conventionally and organically grown ‘Washington Navel’ oranges. Oranges from the conventional and certified organic citrus orchards were harvested at commercial maturity and kept at 4°C for 5 months ...
Elif Çandır, Müge Kamiloğlu, Durmuş Üstün, Gülcan Tuğçe Kendir   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source