Results 31 to 40 of about 27,909 (313)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Agricultural and Food Economics, 2016 Recent years have witnessed closer diplomatic relations between Egypt and Russia, which have led to significant growth in the countries’ bilateral agricultural trade.
Assem Abu Hatab
doaj +1 more source
, 2012 Currently, the concern about the environmental degradation and the conditions of life of our planet has increased. An alarm literally sounded relating the environmental problems and the uncertainties of the future. An energy revolution is necessary in
Luciana Oranges Cezarino
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Implementation of AlexNet and Xception Architectures for Disease Detection in Orange Plants
Journal of Applied Informatics and ComputingOranges are one of Indonesia's primary horticultural commodities, with production increasing each year. However, pest and disease infestations often go undetected, leading to significant reductions in crop yields.
Venus Al Fatah, Moh. Ali Romli
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Multiresidual gas chromatography-tandem mass spectrometry method for determination of plant protection product residues in fruit [PDF]
Journal of Central European AgricultureA multiresidual method for the determination of 29 active substances was developed and validated. Acetone, petroleum ether and dichloromethane were used for extraction, and a gas chromatograph coupled with a tandem mass spectrometer was used for ...
Helena BAŠA ČESNIK
doaj +1 more source
, 2015 Companies find themselves immersed in a complex environment that excels in competitiveness. Competing with competitors, being up to date with competitors in the market, being up to date with legal obligations, and being able to close cash levels of ...
Luciana Oranges Cezarino
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source