Results 91 to 100 of about 329,030 (268)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Spectroscopy and orbital periods of the old novae V533 Herculis, V446 Herculis and X Serpentis [PDF]

, 2000
J. R. Thorstensen, Cynthia J. Taylor
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Catalogue of the orbital elements, masses, and luminosities for short-periodicRS CVn-type eclipsing systems [PDF]

, 2005
G. N. Dryomova, E. L. Perevozkina, M. A. Svechnikov   +2 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pediatric orbital fractures in Singapore: demographics, etiology, and the role of bioresorbable implants

Frontiers in Ophthalmology
PurposeThis study aimed to analyze the demographic characteristics, etiology, fracture types, interventions and treatment outcomes, with a focus on the increasing role of bioresorbable implants compared to traditional non-resorbable implants in pediatric
Emmanuel Lee Boniao, Emmanuel Lee Boniao, Emmanuel Lee Boniao, Emmanuel Lee Boniao, Alexander Gungab, Alexander Gungab, Blanche Xiao Hong Lim, Gangadhara Sundar   +7 more
doaj   +1 more source

π-Orbital Yin–Yang Kagome bands in anilato-based metal–organic frameworks

, 2020
Xiaojuan Ni, Yinong Zhou, Gurjyot Sethi, Feng Liu   +3 more
openalex   +2 more sources

Resolution of refractory orbital cellulitis in an immunocompetent child: A case report

, 2021
Windi Eka Yulia Retnani, Mutmainah Mahyuddin, Sahar S.S. Alatas, Diajeng Ayesha Soeharto   +3 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Site-Selective Orbital Interactions in an Ultrathin Iron-Carbene Photosensitizer Film

, 2020
Robert H. Temperton, Nils W. Rosemann, Meiyuan Guo, Niclas Johansson, Lisa A. Fredin, Om Prakash, Kenneth Wärnmark, Karsten Handrup, Jens Uhlig, Joachim Schnadt, Petter Persson   +10 more
openalex   +1 more source