Results 151 to 160 of about 1,101,620 (303)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Critical Temperature and Tunneling Spectroscopy of Superconductor-Ferromagnet Hybrids with Intrinsic Rashba-Dresselhaus Spin-Orbit Coupling

, 2015
We investigate theoretically how the proximity effect in superconductor/ferromagnet hybrid structures with intrinsic spin-orbit coupling manifests in the density of states and critical temperature. To describe a general scenario, we allow for both Rashba
Jacobsen, Sol H., Linder, Jacob, Ouassou, Jabir Ali   +2 more
core  

Determination of the orbit elements of Comet f 1896 (Perrine)

, 1897
C. J. Merfield
openalex   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Narcisa Garay, mujer para llorar: Semiótica de la escenografía [PDF]

, 1976
Defelitto, Ana M., Negri, Eithel Orbit
core   +2 more sources

Emergent Orbital Dynamics in Strongly Spin-Orbit Coupled Systems [PDF]

arXiv
The interplay between spin and orbital degrees of freedom gives rise to a variety of emergent phases in correlated 4d and 5d transition-metal systems. Strong spin-orbit coupling (SOC) significantly alters Jahn-Teller (JT) physics, often suppressing static distortions or promoting dynamic fluctuations, thereby reducing or even quenching orbital ...
arxiv  

Sarcoma (Small-Celled) of the Right Maxillary Antrum; Moure's Operation of Lateral Rhinotomy (Sept., 1916); Recurrence, Pre-Aural Gland (March, 1917); Margin of Orbit, Right Inner Canthus (July, 1918); Right Breast and Axilla (Aug., 1919); Growth Dispersed by Radium

, 1922
Irwin Moore
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Eosinophilic Granuloma of the Orbit [PDF]

, 1951
Aaron J. Beller, Walter Kornblueth
openalex   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source