Results 131 to 140 of about 3,161,815 (352)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Special studies of AROD systems, concepts and designs Final report [PDF]

Design and evaluation of development model for airborne range and orbit determination ...
Ghais, A. F.
core   +1 more source

Determination of the orbital parameters of binary pulsars [PDF]

, 2008
Bhaswati Bhattacharyya, Rajaram Nityananda   +1 more
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

First Use of Laser Ranging to Surface Retroreflectors for Orbit Determination: LRO-LOLA at the Moon

The Planetary Science Journal
We document the first operational demonstration of two-way spacecraft-to-surface laser ranging using Laser Retroreflector Arrays (LRAs) for orbit determination (OD) of the Lunar Reconnaissance Orbiter (LRO).
G. Cascioli, E. Mazarico, D. R. Cremons, M. K. Barker, D. Mao, S. Goossens, V. Viswanathan, S. Bertone, K. Jha, F. G. Lemoine, X. Sun, J. W. Head, D. E. Smith, M. T. Zuber   +13 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Realtime Precise Orbit Determination Technology for LEO Mega-Constellation

天地一体化信息网络
Supported by GNSS, it analyzed the advantages and disadvantages of solving LEO satellite orbit on the ground or onboard the satellites.The high-fidelity non-conservative force models were applied to the real-time orbit determination algorithm.To separate
Zhen LI, Chuang SHI
doaj   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bistatic SAR Imaging and Precise Orbit Determination Using Geostationary Telecommunication Satellites

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
SAR satellite missions from geostationary orbits (GEOSAR) would offer the short revisit times required in the observation of fast phenomena. Ground-based multiple baseline interferometry is a technique under study for precise orbit determination of GEO ...
Xavier Carreno-Megias, Jorge Nicolas-Alvarez, Antoni Broquetas, Albert Aguasca, Joan Cuy-Saques, Marius Gutierrez   +5 more
doaj   +1 more source

A multi-satellite orbit determination problem in a parallel processing environment [PDF]

The Engineering Orbit Analysis Unit at GE Valley Forge used an Intel Hypercube Parallel Processor to investigate the performance and gain experience of parallel processors with a multi-satellite orbit determination problem.
Anderle, R. J., Deakyne, M. S.
core   +1 more source