Results 131 to 140 of about 3,183,096 (399)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

First Use of Laser Ranging to Surface Retroreflectors for Orbit Determination: LRO-LOLA at the Moon

The Planetary Science Journal
We document the first operational demonstration of two-way spacecraft-to-surface laser ranging using Laser Retroreflector Arrays (LRAs) for orbit determination (OD) of the Lunar Reconnaissance Orbiter (LRO).
G. Cascioli, E. Mazarico, D. R. Cremons, M. K. Barker, D. Mao, S. Goossens, V. Viswanathan, S. Bertone, K. Jha, F. G. Lemoine, X. Sun, J. W. Head, D. E. Smith, M. T. Zuber   +13 more
doaj   +1 more source

Special studies of AROD systems, concepts and designs Final report [PDF]

Design and evaluation of development model for airborne range and orbit determination ...
Ghais, A. F.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Probabilistic Initial Orbit Determination

, 2016
Future space surveillance requires dealing with uncertainties directly in the initial orbit determination phase. We propose an approach based on Taylor differential algebra to both solve the initial orbit determination (IOD) problem and to map uncertainties from the observables space into the orbital elements space. This is achieved by approximating in
ARMELLIN, ROBERTO, DI LIZIA, PIERLUIGI
openaire   +3 more sources

A demonstration of high precision GPS orbit determination for geodetic applications [PDF]

High precision orbit determination of Global Positioning System (GPS) satellites is a key requirement for GPS-based precise geodetic measurements and precise low-earth orbiter tracking, currently under study at JPL.
Border, J. S., Lichten, S. M.
core   +1 more source

Autonomous navigation accuracy using simulated horizon sensor and sun sensor observations [PDF]

, 1980
A relatively simple autonomous system which would use horizon crossing indicators, a sun sensor, a quartz oscillator, and a microprogrammed computer is discussed.
Hendrickson, H. T., Pease, G. E.
core   +1 more source

Experimental verification of possibility of spacecraft initial orbit determination using radial velocity measured by one measuring point [PDF]

, 2001
A.D. Sheptun, Oleg Ivanov, I.V. Mashtak, Yuzhnoye State Design Office, Dnipro, Ukraine, I.V. Mashtak, Yangel Yuzhnoye State Design Office, Dnipro, Ukraine   +5 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source