Results 51 to 60 of about 318,817 (173)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Test and Performance Analysis Methods of Low Earth Orbit GPS Receiver [PDF]

open access: yesJournal of Astronomy and Space Sciences, 2006
The use of GPS receiver at outer space becomes common in low earth orbit. Recently most of satellites use GPS receiver as navigation solution for finding satellite position.
Dae-Won Chung, Sang-Jeong Lee
doaj   +1 more source

Orbit Determination Before Detect: Orbital Parameter Matched Filtering for Uncued Detection [PDF]

open access: yesarXiv, 2020
This paper presents a novel algorithm to incorporate orbital parameters into radar ambiguity function expressions by extending the standard ambiguity function to match Keplerian two-body orbits. A coherent orbital matched-filter will maximise a radar's sensitivity to objects in orbit, as well as provide rapid initial orbit determination from a single ...
arxiv  

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Geostationary Orbit Surveillance Using the Unscented Kalman Filter and the Analytical Orbit Model [PDF]

open access: yesJournal of Astronomy and Space Sciences, 2011
A strategy for geostationary orbit (or geostationary earth orbit [GEO]) surveillance based on optical angular observations is presented in this study. For the dynamic model, precise analytical orbit model developed by Lee et al.
Kyoung-Min Roh   +2 more
doaj   +1 more source

Geometry of orbits of permanents and determinants [PDF]

open access: yesarXiv, 2010
We prove that the orbit closure of the determinant is not normal. A similar result is obtained for the orbit closure of the permanent multiplied by a power of a linear form.
arxiv  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

LEO Enhanced Global Navigation Satellite System (LeGNSS): progress, opportunities, and challenges

open access: yesGeo-spatial Information Science, 2021
With the completion of Chinese BeiDou Navigation Satellite System (BDS), the world has begun to enjoy the Positioning, Navigation, and Timing (PNT) services of four Global Navigation Satellite Systems (GNSS).
Haibo Ge   +8 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy