Results 131 to 140 of about 31,208 (318)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Magnetization dynamics driven by non-equilibrium spin-orbit coupled electron gas
New Journal of Physics, 2015 The dynamics of magnetization coupled with an electron gas via s-d exchange interaction is investigated by using the density matrix technique. Our theory shows that nonequilibrium spin accumulation induces a spin torque and the electron bath leads to a ...
Yong Wang, Wei-qiang Chen, Fu-Chun Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
A passive de-orbiting strategy for high altitude CubeSat missions using a deployable reflective balloon [PDF]
, 2011 A de-orbiting strategy for small satellites, in particular CubeSats, is proposed which exploits the effect of solar radiation pressure to increase the spacecraft orbit eccentricity so that the perigee falls below an altitude where atmospheric drag will ...
Colombo, Camilla +2 more
core
Emergent orbital dynamics in strongly spin-orbit coupled systems
Physical Review BThe interplay between spin and orbital degrees of freedom gives rise to a variety of emergent phases in correlated 4d and 5d transition-metal systems. Strong spin-orbit coupling (SOC) significantly alters Jahn-Teller (JT) physics, often suppressing static distortions or promoting dynamic fluctuations, thereby reducing or even quenching orbital ...
A. S. Miñarro, G. Herranz
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Comparative study on the application of evolutionary optimization techniques to orbit transfer maneuvers [PDF]
, 2008 Orbit transfer maneuvers are here considered as benchmark cases for comparing performance of different optimization techniques in the framework of direct methods. Two different classes of evolutionary algorithms, a conventional genetic algorithm and an
Avanzini, Giulio +3 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Phoenix-XNS - A Miniature Real-Time Navigation System for LEO Satellites [PDF]
, 2006 The paper describes the development of a miniature GPS receiver with integrated real-time navigation system for orbit determination of satellites in low Earth orbit (LEO).
Gill, Eberhard, Montenbruck, Oliver
core