Results 141 to 150 of about 31,208 (318)

Aligning Initial Conditions With Long‐Term Model Dynamics to Enhance 4DVar‐Driven Medium‐Range Global Forecasts

Geophysical Research Letters
Applying the four‐dimensional variational (4DVar) method in nonlinear systems faces conflicts between a lack of long‐term dynamical information using a short assimilation window and a trap of local minima using a long window.
Shujun Zhu, Bin Wang, Lin Zhang, Juanjuan Liu, Yongzhu Liu, Jiandong Gong, Lijuan Li, Shiming Xu, Yong Wang, Wenyu Huang, Li Liu, Yujun He, Lan Xu, Jilin Wang   +13 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Relative orbit dynamics in near-geostationary orbit [PDF]

, 2015
A relative motion model for a Client and a Servicer spacecraft in near geostationary orbit is developed taking into account various gravitational and non-gravitational forces. In particular, differential perturbations due to Earth’s oblateness, solar radiation pressure and third body gravitational pull are studied, quantified and modeled.
Spiridonova, Sofya, Kahle, Ralph
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Collision Avoidance Operations for LEO Satellites Controlled by GSOC [PDF]

, 2010
The ever increasing population of objects in the near Earth environment has created growing concerns among satellite owners and control centers about the safety of their missions.
Kiehling, Reinhard, Aida, Saika, Kirschner, Michael, Wermuth, Martin   +3 more
core  

Excitation of coupled spin-orbit dynamics in cobalt oxide by femtosecond laser pulses. [PDF]

Nat Commun, 2017
Satoh T, Iida R, Higuchi T, Fujii Y, Koreeda A, Ueda H, Shimura T, Kuroda K, Butrim VI, Ivanov BA.   +9 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Long term nonlinear propagation of uncertainties in perturbed geocentric dynamics using automatic domain splitting [PDF]

, 2014
Current approaches to uncertainty propagation in astrodynamics mainly refer tolinearized models or Monte Carlo simulations. Naive linear methods fail in nonlinear dynamics, whereas Monte Carlo simulations tend to be computationallyintensive. Differential
Makino, Kyoko, Wittig, A, Bernelli-Zazzera, Franco, Zazzera, FB, Di Lizia, Pierluigi, Wittig, Alexander, Makino, K, Armellin, Roberto, Armellin, R, Berz, M., Di Lizia, P, WITTIG, ALEXANDER NICOLAUS, Makino, K., Berz, M, BERNELLI ZAZZERA, FRANCO, Berz, Martin, Zazzera, Franco Bernelli   +16 more
core  

Modeling and Optimization of Trans-lunar Orbit for Lunar Polar Station

Kongzhi Yu Xinxi Jishu, 2019
Lunar polar station is one of the effective ways for private lunar tourism and lunar surface global access mission in the future, the station resupply mission requires a modeling and optimization method for a two-impulse trans-lunar orbit with high ...
HE Boyong
doaj  

Ground-Based Testing of In-Orbit Interactions Under Scale and Time-Delay Limitations

IEEE Access
On-ground facilities provide opportunities for robot-assisted emulation of on-orbit space operations; however, they present unique challenges, including accurately scaling satellite dynamics for laboratory environments, ensuring stable motion-execution ...
Mohatashem Reyaz Makhdoomi, Baris Can Yalcin, Vivek Muralidharan, Georges Mett Kremer, Juan Sandoval, Miguel Olivares-Mendez, Carol Martinez   +6 more
doaj   +1 more source