Results 71 to 80 of about 487,216 (307)

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Shadowing Lemma and Chaotic Orbit Determination [PDF]

open access: yes, 2015
Orbit determination is possible for a chaotic orbit of a dynamical system, given a finite set of observations, provided the initial conditions are at the central time. In a simple discrete model, the standard map, we tackle the problem of chaotic orbit determination when observations extend beyond the predictability horizon. If the orbit is hyperbolic,
arxiv   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

open access: yesFEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine   +3 more
wiley   +1 more source

Verification of KAM Theory on Earth Orbiting Satellites [PDF]

open access: yes, 2010
This paper uses KAM torus theory and Simplified General Perturbations 4 (SGP4) orbit prediction techniques compiled by Dr. William Wiesel and compares it to Analytical Graphics ® Incorporated (AGI) Satellite Toolkit ® (STK) orbit data.
Bisher, Christian L.
core   +1 more source

Neutron $2p$ and $1f$ spin--orbit splittings in $^{40}$Ca, $^{36}$S, and $^{34}$Si $N=20$ isotones: tensor--induced and pure spin--orbit effects

open access: yes, 2015
Neutron $2p$ and $1f$ spin--orbit splittings were recently measured in the isotones $^{37}$S and $^{35}$Si by $(d,p)$ transfer reactions. Values were reported by using the major fragments of the states.
Anguiano, M., Grasso, M.
core   +3 more sources

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Semiclassical Theory for Parametric Correlation of Energy Levels

open access: yes, 2006
Parametric energy-level correlation describes the response of the energy-level statistics to an external parameter such as the magnetic field. Using semiclassical periodic-orbit theory for a chaotic system, we evaluate the parametric energy-level ...
Berry M V   +17 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

First-principles calculations and experimental studies of: XYZ 2 thermoelectric compounds: Detailed analysis of van der Waals interactions [PDF]

open access: yes, 2018
First-principles calculations can accelerate the search for novel high-performance thermoelectric materials. However, the prediction of the thermoelectric properties is strongly dependent on the approximations used for the calculations.
Aydemir, U   +13 more
core  

A New Spin-Orbit Induced Universality Class in the Quantum Hall Regime ?

open access: yes, 2001
Using heuristic arguments and numerical simulations it is argued that the critical exponent $\nu$ describing the localization length divergence at the quantum Hall transition is modified in the presence of spin-orbit scattering with short range ...
A. Kawabata   +19 more
core   +1 more source

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