Results 51 to 60 of about 4,035,131 (289)

An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems

Scientific Reports
This study proposes an integrated framework that combines Axiomatic Design with Model-Based Systems Engineering, incorporating NSGA-II as an intelligent optimization engine. The framework constructs a multi-level traceability matrix linking requirements,
Xiaoqian Zhang, Qinghai Zhang, Qingjian Zhao, Shuang Zhao, Yanan Zhao, Yang Guo, Zhengxu Zhao, Liqiang Song   +7 more
doaj   +1 more source

A Hybrid EMD-ICA-DLinear Multi-View Representation Model for Accurate Satellite Orbit Prediction in Space

Aerospace
Accurate prediction of the on-orbit positions of Low Earth Orbit (LEO) satellites is essential for mission success, operational efficiency, and safety.
Yang Guo, Boyang Wang, Zhengxu Zhao
doaj   +1 more source

A Case Study on the Effect of Atmospheric Density Calibration on Orbit Predictions with Sparse Angular Data

Remote Sensing, 2023
Accurately modeling the density of atmospheric mass is critical for orbit determination and prediction of space objects. Existing atmospheric mass density models (ADMs) have an accuracy of about 15%.
Junyu Chen, Jizhang Sang, Zhenwei Li, Chengzhi Liu   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Bayesian Adaptive Extended Kalman-Based Orbit Determination for Optical Observation Satellites

Sensors
As the number of satellites and amount of space debris in Low-Earth orbit (LEO) increase, high-precision orbit determination is crucial for ensuring the safe operation of spacecraft and maintaining space situational awareness.
Yang Guo, Qinghao Pang, Xianlong Yin, Xueshu Shi, Zhengxu Zhao, Jian Sun, Jinsheng Wang   +6 more
doaj   +1 more source

Ballistic Coefficient Calculation Based on Optical Angle Measurements of Space Debris

Sensors, 2023
Atmospheric drag is an important factor affecting orbit determination and prediction of low-orbit space debris. To obtain accurate ballistic coefficients of space debris, we propose a calculation method based on measured optical angles.
Yigao Ding, Zhenwei Li, Chengzhi Liu, Zhe Kang, Mingguo Sun, Jiannan Sun, Long Chen   +6 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Orbit Determination Error Analysis for a future Space Debris Tracking Radar [PDF]

, 2011
Independent of light and weather conditions radar systems provide observations of space debris in low and medium earth orbits. In general two operational principles can be distinguished - in survey mode all objects passing through the radar instrument ...
Patyuchenko, Anton, Weigel, Martin
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source