Results 11 to 20 of about 90,785 (259)

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Journal of Experimental & Clinical Cancer Research, 2022
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation.
Yidian Fu, Jie Yu, Fang Li, Shengfang Ge
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Management of Unsatisfactory Postoperative Double Eyelid With Intralesional Corticosteroid Injection

Frontiers in Medicine, 2021
Purpose: The present study was designed to observe the curative effect of early intralesional corticosteroid injection to treat unsatisfactory double eyelid.Methods: This retrospective, observational study included 30 female patients (age 22–35 years ...
Siyi Zhang, Siyi Zhang, Yixiong Zhou, Yixiong Zhou, Fei Yu, Fei Yu, Dan Yan, Dan Yan, Yan Yan, Yan Yan, Meng Zhou, Meng Zhou, Yao Fu, Yao Fu, Yang Lu, Yang Lu   +15 more
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Sperm-Specific Glycolysis Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Regulated by Transcription Factor SOX10 to Promote Uveal Melanoma Tumorigenesis

Frontiers in Cell and Developmental Biology, 2021
Melanoma cells exhibit increased aerobic glycolysis, which represents a major biochemical alteration associated with malignant transformation; thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy.
Xia Ding, Xia Ding, Lihua Wang, Lihua Wang, Mingjiao Chen, Mingjiao Chen, Yue Wu, Yue Wu, Shengfang Ge, Shengfang Ge, Jin Li, Jin Li, Xianqun Fan, Xianqun Fan, Ming Lin, Ming Lin   +15 more
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Oncolytic Virotherapy: From Bench to Bedside

Frontiers in Cell and Developmental Biology, 2021
Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years.
Ludi Yang, Ludi Yang, Xiang Gu, Xiang Gu, Jie Yu, Jie Yu, Shengfang Ge, Shengfang Ge, Xianqun Fan, Xianqun Fan   +9 more
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Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

Journal of Pharmaceutical Analysis, 2023
Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis.
Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan   +8 more
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Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis

Journal of Hematology & Oncology, 2020
The novel coronavirus (2019-nCoV) is an emerging causative agent that was first described in late December 2019 and causes a severe respiratory infection in humans. Notably, many of affected patients of COVID-19 were people with malignancies.
Peiwei Chai, Jie Yu, Shengfang Ge, Renbing Jia, Xianqun Fan   +4 more
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Nomogram for Preoperative Estimation of Orbit Invasion Risk in Periocular Squamous Cell Carcinoma

Frontiers in Oncology, 2020
Importance: Orbital invasion occurs in some periocular squamous cell carcinoma (SCC), compromising surgical outcomes, and prognoses of patients. To date, however, there are no validation studies on the clinical features related to orbital invasion in ...
Minyue Xie, Minyue Xie, Jie Yu, Jie Yu, Lunhao Li, Lunhao Li, Renbing Jia, Renbing Jia, Xin Song, Xin Song, Yefei Wang, Yefei Wang, Xianqun Fan, Xianqun Fan   +13 more
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Lymphoproliferative Disease of the Orbit

Asia-Pacific Journal of Ophthalmology, 2015
Lymphoproliferative diseases of the orbit account for majority of orbital tumors. The pathologies range from reactive lymphoid hyperplasia to specific IgG4-related inflammation to malignant lymphomas. This review summarizes current concepts regarding pathology, clinical presentation, diagnosis, staging, and treatment strategies of major orbital ...
Emmy Y, Li, Hunter K, Yuen, Wah, Cheuk
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Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT

Global Challenges, 2022
Oncological diseases have become the second leading cause of death from noncommunicable diseases worldwide and a major threat to human health. With the continuous progress in cancer research, the mechanical cues from the tumor microenvironment ...
Hao Tian, Hanhan Shi, Jie Yu, Shengfang Ge, Jing Ruan   +4 more
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miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells

Frontiers in Cell and Developmental Biology, 2022
Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is a major kind of ocular diseases causing blindness.
Jiajing Wang, Jiajing Wang, Na Sun, Na Sun, Yahan Ju, Yahan Ju, Ni Ni, Ni Ni, Zhimin Tang, Zhimin Tang, Dandan Zhang, Dandan Zhang, Xiaochan Dai, Moxin Chen, Moxin Chen, Yiqi Wang, Yiqi Wang, Ping Gu, Ping Gu, Jing Ji, Jing Ji   +20 more
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