Results 21 to 30 of about 90,785 (259)

Study of Cinobufagin as a Promising Anticancer Agent in Uveal Melanoma Through Intrinsic Apoptosis Pathway

open access: yesFrontiers in Oncology, 2020
Uveal melanoma (UM) is the most common primary intraocular carcinoma in adults. Cinobufagin, secreted by the Asiatic toad Bufo gargarizans, is a traditional Chinese medicine, widely used in tumor treatment.
Leilei Zhang   +11 more
doaj   +1 more source

HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration

open access: yesRedox Biology, 2021
Oxidative stress-mediated retinal pigment epithelium (RPE) degeneration plays a vital role in retinal degeneration with irreversible visual impairment, most notably in age-related macular degeneration (AMD), but a key pathogenic factor and the targeted ...
Zhimin Tang   +9 more
doaj   +1 more source

FBXO38 regulates ocular melanoma proliferation through the PI3K-Akt signaling pathway

open access: yesShanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effect of F-box only protein 38 (FBXO38) on the ocular melanoma proliferation and the potential regulatory pathway.Methods·Human skin cutaneous melanoma A375 and human uveal melanoma OMM2.3 cell lines with FBXO38 knockdown ...
WU Yijia   +5 more
doaj   +1 more source

Cell-free matrix derived from adipose mesenchymal stromal cells enhances corneal rehabilitation via delivery of nerve regenerative PGRN

open access: yesMaterials & Design, 2023
Promotion of corneal dense network of nerve is a promising method to treat severe corneal injury, yet with limited effective drugs. In our previous work, decellularized matrix of adipose derived mesenchymal stromal cells (ADMSCs), named as DMA, presented
Dan Yan   +5 more
doaj   +1 more source

Prognostic factors of traumatic optic neuropathy based on multimodal analysis—Especially the influence of postoperative dressing change and optic nerve blood supply on prognosis

open access: yesFrontiers in Neurology, 2023
ObjectiveTo investigate the critical prognostic factors of patients with traumatic optic neuropathy (TON) treated with endoscopic transnasal optic canal decompression (ETOCD) and to perform multimodal analysis based on imaging examinations of optical ...
Xueru Liu   +11 more
doaj   +1 more source

Cathelicidin LL37 Promotes Osteogenic Differentiation in vitro and Bone Regeneration in vivo

open access: yesFrontiers in Bioengineering and Biotechnology, 2021
Different types of biomaterials have been used to repair the defect of bony orbit. However, exposure and infections are still critical risks in clinical application.
Lunhao Li   +11 more
doaj   +1 more source

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

open access: yesFrontiers in Genetics, 2022
This study was designed to identify differently expressed circular RNAs (circRNAs) and investigate their potential roles in lacrimal sacs from patients with chronic dacryocystitis.
Yue Li   +11 more
doaj   +1 more source

Novel insight into RNA modifications in tumor immunity: Promising targets to prevent tumor immune escape

open access: yesThe Innovation, 2023
An immunosuppressive state is a typical feature of the tumor microenvironment. Despite the dramatic success of immune checkpoint inhibitor (ICI) therapy in preventing tumor cell escape from immune surveillance, primary and acquired resistance have ...
Yuxin Kong   +3 more
doaj   +1 more source

Effects of cancer on patients with COVID-19: a systematic review and meta-analysis of 63,019 participants

open access: yesCancer Biology & Medicine, 2021
Objective: Patients with underlying diseases are more vulnerable to coronavirus disease 2019 (COVID-19). The purpose of this study was to investigate cancer incidence in patients with COVID-19 and to determine whether cancer was associated with mortality
Ludi Yang   +3 more
doaj   +1 more source

Identification of immune hub genes participating in the pathogenesis and progression of Vogt-Koyanagi-Harada disease

open access: yesFrontiers in Immunology, 2022
BackgroundVogt-Koyanagi-Harada (VKH) disease is an autoimmune inflammatory disorder characterized by bilateral granulomatous uveitis. The objective of this study was to identify immune hub genes involved in the pathogenesis and progression of VKH disease.
Yiqi Wang   +14 more
doaj   +1 more source

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