Results 121 to 130 of about 102,497 (301)

Rapid Characterization and Identification of Non-Diterpenoid Constituents in Tinospora sinensis by HPLC-LTQ-Orbitrap MSn

Molecules, 2018
Tinospora sinensis, a kind of Chinese folk medicine, has functions of harmonizing qi and blood, dredging the channels and collaterals, calming and soothing the nerves. In the present study, a method based on high-performance liquid chromatography coupled
Qi-Shu Jiao, Lu-Lu Xu, Jia-Yu Zhang, Zi-Jian Wang, Yan-Yan Jiang, Bin Liu   +5 more
doaj   +1 more source

ESI-Orbitrap sulphate isotopologue data for Dome C aerosol samples

These ESI-Orbitrap MS sulphate isotopologue data quantify d34S-SO4, D33S-SO4, d18O-SO4 and D17O-SO4 in selected high-volume aerosol samples collected outside Concordia station (75°06'S, 123°20'E, 3233 m a.s.l.) from January - December 2011.
Saville, Jack
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Orbitrap noise structure and method for noise unbiased multivariate analysis

Nature Communications
Orbitrap mass spectrometry is widely used in the life-sciences. However, like all mass spectrometers, non-uniform (heteroscedastic) noise introduces bias in multivariate analysis complicating data interpretation.
Michael R. Keenan, Gustavo F. Trindade, Alexander Pirkl, Clare L. Newell, Yuhong Jin, Konstantin Aizikov, Andreas Dannhorn, Junting Zhang, Lidija Matjačić, Henrik Arlinghaus, Anya Eyres, Rasmus Havelund, Richard J. A. Goodwin, Zoltan Takats, Josephine Bunch, Alex P. Gould, Alexander Makarov, Ian S. Gilmore   +17 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Identification of Quality Markers in Schisandra chinensis (Turcz.) Baill. Using UPLC-Q-Extractive Orbitrap/MS, Chemometric Analysis, and Network Pharmacology

Separations
Chemical composition is a critical factor for determining the efficacy of any traditional Chinese medicine (TCM) and can be used as an indicator of commercial quality. To develop a new strategy for discovering potential quality markers (Q-markers) of TCM
Yinpeng Wang, Yumei Li, Yan Ding, Xinxin Du, Jingbo Zhu   +4 more
doaj   +1 more source

sj-docx-1-npx-10.1177_1934578X241235749 - Supplemental material for Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n-Butanol Part of Mume Flos

Supplemental material, sj-docx-1-npx-10.1177_1934578X241235749 for Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n-Butanol Part of Mume Flos
Deling Wu (12325259), Chuanshan Jin (14018490), Xue Wang (102830), Hongsu Zhao (18131829), Wei Zhang (405), Yijie Gan (18131832), Shurong Zhang (11009222), Mengying Wu (8858786), Jinmei Ou (10966023)   +8 more
core   +1 more source

Data_Sheet_1_Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis.doc

, 2019
The dry roots of Polygonum multiflorum (PM), involving both the raw and processed materials, are widely used as the traditional Chinese medicine for treating various diseases in China. Hepatotoxicity has been occasionally reported in patients who consume
Caixiang Liu (2247232), Fang Zheng (54278), Wenzhi Yang (298905), Zhiying Dou (6592826), Qianyu Zhao (6436865), Piao Wang (6592823), Limin Hu (221823), Lifeng Han (375604), Yulan Wang (50197)   +8 more
core   +1 more source

Water‐Soluble POSS Promotes Concurrent Coalescence and Crosslinking for Multiscale‐Reinforced, Coalescent‐Free Waterborne Coatings

Advanced Science, EarlyView.
Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang, Bin Wu, Lin Li, Yibo Ru, Xiaohe Zhang, Minlong Wang, Ruoyan Yang, Jie An   +7 more
wiley   +1 more source