Results 141 to 150 of about 102,497 (301)

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

The OrbiTOF Mass Analyzer: Time-of-Flight Analysis via an Orbitrap Quadro-Logarithmic Field with Periodic Drift Focusing. [PDF]

Thermo Scientific™ Orbitrap™ analyzers represent prominent class of high-resolution mass analyzer commonly used in life sciences, and for interrogation of complex samples.
Dmitry, Grinfeld, Matthias, Biel, Alexander, Makarov, Anastassios, Giannakopulos, Christian, Hock, Wilko, Balschun, Hamish, Stewart   +6 more
core   +2 more sources

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Improving molecular-level understanding of atmospheric oxygenated organic molecules using online high-resolution orbitrap mass spectrometry

Atmospheric oxygenated organic molecules (OOMs) are key intermediates driving secondary organic aerosol (SOA) formation and new particle growth, yet their molecular-level characterization is constrained by the insufficient mass resolution of current ...
Guo, Song (author), El Haddad, Imad (author), Hu, Weiwei (author), Liu, Xiao (author), Liu, Jiayuan (author), Cai, Runlong (author), Mao, Hongjun (author), Feng, Zeyu (author), Peng, Jianfei (author), Hu, Min (author), Kangasluoma, Juha (author), Tang, Lizi (author), Wang, Yajie (author), Guo, Jiliang (author), Zhang, Jinsheng (author), Shang, Dongjie (author), Yuan, Yi (author)   +16 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Analysis of Chemical Components and Blood‐Absorbed Components in Youjing Granules by UHPLC‐Q‐Orbitrap‐MS

Analytical Science Advances
This study investigates the chemical components of Youjing Granules (YG) and identifies blood‐absorbed components in rat serum following YG administration via gavage.
Mingxin Guo, Jiaqi Zeng, Xuping Jiang, Wenjiao Zhu, Zhian Tang, Tieliang Ma   +5 more
doaj   +1 more source

Screening of the Active Components of Qinbai Qingfei Concentrated Pill on Treating Pneumonia Based on UHPLC/Q-Exactive Orbitrap MS Uniting Network Pharmacology

Zhipu Xuebao
In order to screen the active ingredients of Qinbai Qingfei Concentrated Pill (QQCP) on treating pneumonia contributed by Pheretima, the extracts of QQCP with and without Pheretima were detected by ultra-high performance liquid chromatography/quadrupole ...
Yang YU, Yang XIN, Hai-jun WANG, Qing-zhu YANG, Wei-ming WANG   +4 more
doaj   +1 more source

Peptide sequences from SjAgo2 and paramyosin identified by Orbitrap MS from 27A9 immunoprecipitation.

, 2012
Peptide sequences from SjAgo2 and paramyosin identified by Orbitrap MS from 27A9 immunoprecipitation.
Pengfei Cai (145966), Xianyu Piao (145967), Shuai Liu (145969), Heng Wang (76752), Qijun Chen (21638), Nan Hou (145968)   +5 more
core   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source