Results 101 to 110 of about 1,309 (131)

MCM Double Hexamer Loading Visualised with Human Proteins

Weissmann F, Greiwe JF, Pühringer T, Miller TCR, Diffley JFX, Costa A.   +5 more
europepmc   +1 more source

Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function

Lim CT, Miller TC, Tan KW, Tan KW, Talele S, Early A, East P, Sánchez H, Dekker NH, Costa A, Diffley JF.   +10 more
europepmc   +1 more source

Orc6 is a component of the replication fork and enables efficient mismatch repair

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Origin recognition complex (ORC) is required for the initiation of DNA replication. Unlike other ORC components, the role of human Orc6 in replication remains to be resolved. We identified an unexpected role for hOrc6, which is to promote S-phase progression after prereplication complex assembly and DNA damage response ...
Jaba Mitra, Supriya Prasanth, Qinyu Hao   +2 more
exaly   +3 more sources

Identification and Characterization of the Human ORC6 Homolog [PDF]

Journal of Biological Chemistry, 2000
A new protein was cloned and identified as the sixth member of the human origin recognition complex (ORC). The newly identified 30-kDa protein hsORC6 is 28% identical and 49% similar to ORC6p from Drosophila melanogaster, which is consistent with the identities and similarities found among the other ORC members reported in the two species.
Anindya Dutta
exaly   +3 more sources

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Different roles of the human Orc6 protein in the replication initiation process

Cellular and Molecular Life Sciences, 2011
In eukaryotes, binding of the six-subunit origin recognition complex (ORC) to DNA provides an interactive platform for the sequential assembly of pre-replicative complexes. This process licenses replication origins competent for the subsequent initiation step.
Manfred Gossen, Wolfgang Hammerschmidt, Aloys Schepers   +2 more
exaly   +3 more sources

Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA [PDF]

Nucleic Acids Research, 2020
AbstractThe six-subunit origin recognition complex (ORC), a DNA replication initiator, defines the localization of the origins of replication in eukaryotes. The Orc6 subunit is the smallest and the least conserved among ORC subunits. It is required for DNA replication and essential for viability in all species.
Hongyu Yang, Rahman Ud Din, Igor Chesnokov   +2 more
exaly   +4 more sources

Orc6 Involved in DNA Replication, Chromosome Segregation, and Cytokinesis

Science, 2002
Origin recognition complex (ORC) proteins serve as a landing pad for the assembly of a multiprotein prereplicative complex, which is required to initiate DNA replication. During mitosis, the smallest subunit of human ORC, Orc6, localizes to kinetochores and to a reticular-like structure around the cell periphery.
Supriya Prasanth, Bruce Stillman, Kannanganattu Prasanth   +2 more
exaly   +3 more sources

Meier–Gorlin Syndrome: Clinical Misdiagnosis, Genetic Testing and Functional Analysis of ORC6 Mutations and the Development of a Prenatal Test

International Journal of Molecular Sciences, 2022
Meier–Gorlin syndrome (MGS) is a rare genetic developmental disorder that causes primordial proportional dwarfism, microtia, the absence of or hypoplastic patellae and other skeletal anomalies. Skeletal symptoms overlapping with other syndromes make MGS difficult to diagnose clinically.
Maria Nazarenko, Mikhail Skoblov, Iuliia Viakhireva   +2 more
exaly   +3 more sources

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2–7 loading [PDF]

Genes and Development, 2007
The origin recognition complex (ORC) nucleates DNA replication initiation in eukaryotic cells. This six-protein complex binds replication origin DNA, recruits other initiation factors, and facilitates loading of the DNA helicase.
Stephen P Bell
exaly   +3 more sources