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Essential functions of Cdt1 and Orc6 during origin licensing
Origin licensing ensures that eukaryotic cells replicate their DNA precisely once per cell cycle. The ORC complex, together with the licensing factors Cdc6 and Cdt1, load the core of the replicative helicase (M2-7), as a double hexamer (DH). Licensing starts assembling the helicase loaders ring around duplex DNA (ORC/Cdc6 or OC).openaire +2 more sources
The role of Orc6 in ORC binding-site switching during helicase loading
DNA replication is a fundamental cellular process that enables proper maintenance of genomic integrity and cellular identity as cells divide. Initiation of bidirectional DNA replication is a key requirement for complete duplication of the genome. The first step in eukaryotic DNA replication is origin licensing, during which the origin recognition ...openaire +1 more source
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2002
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Functional insight into the role of Orc6 in septin complex filament formation inDrosophila
Molecular Biology of the Cell, 2015Igor Chesnokov +2 more
exaly
TRPS1 inhibits cervical cancer progression by suppressing ORC6-mediated tumor stemness
Tissue and CellJuan He +12 more
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