Results 111 to 120 of about 1,309 (131)
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Evidence of positive selection at codon sites localized in the C-terminal peptide of ORC6
Biotechnology Letters, 2013Origin recognition complex 6 (Orc6) plays a central role in the initiation of DNA replication in all eukaryotic systems. The exact contribution of Orc6 to replication initiation has yet to be elucidated. Here, we analyzed the evolutionary dynamics of Orc6 in 15 vertebrates. Positive selection was detected in the region of exon 6 of the Orc6 gene.
Tonghai Dou
exaly +3 more sources
Structural and functional study of human Orc6 binding with DNA
2020DNA replication process is tightly controlled in space and time. The binding of Origin Recognition Complex (ORC) to origins of replication serves as a scaffold for the assembly of a multi-protein replicative complex to initiate DNA replication in eukaryotic cells.
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The role of ORC6 in the human cell
2014Orc6 is a crucial component of the replication initiation machinery in eukaryotes. Its study helps us to better understand one of the most basic cell functions: DNA replication. The first step in replication initiation is the assembly and DNA binding of the origin recognition complex (ORC). Although members of ORC are highly conserved and well studied,
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A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression
Experimental Cell ResearchProstate cancer (PCa) is the most prevalent malignant tumor of the genitourinary system, and metastatic disease has a significant impact on the prognosis of PCa patients. As a result, knowing the processes of PCa development can help patients achieve better outcomes. Here, we investigated the expression and function of ORC6 in PCa.
Zhiqi, Liu +4 more
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Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System
Science, 1993Here a method is described to identify genes encoding proteins that recognize a specific DNA sequence. A bank of random protein segments tagged with a transcriptional activation domain is screened for proteins that can activate a reporter gene containing the sequence in its promoter.
J J, Li, I, Herskowitz
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[Genetic analysis of a child with Meier-Gorlin syndrome due to a variant of ORC6 gene].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2023To analyze the genetic characteristics of a child with Meier-Gorlin syndrome (MGS) due to a homozygous variant of the ORC6 gene.A child who was admitted to the Children's Hospital Affiliated to Soochow University on March 25, 2019 due to growth retardation was selected as the study subject. Clinical data of the child was collected.
Lili, Wang +3 more
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Structural studies of Cba3 and biochemical studies of human Orc6
2014In the first part of this dissertation, the structural studies of Cba3 were described. Cellulose is the main structural component of the plant cell wall, the most abundant polysaccharide on Earth, and an important renewable resource. It consists of D-glucose residues linked by β-1,4-glycosidic bonds to form linear polymeric chains of over 10,000 ...
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Mechanistic study on the liquid-liquid phase separation of human Orc6 induced by DNA
2023DNA replication licensing is tightly controlled to ensure that genomic DNA replication happens only once in eukaryotic cells. The six-subunit origin recognition complex (ORC) is a DNA replication initiator which localized at the replication origin for the assembly of the pre-replication complex which is important for the initiation of DNA replication ...
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American Journal of Medical Genetics Part A, 2015
Mutations in genes encoding the origin recognition complex subunits cause Meier–Gorlin syndrome. The disease manifests a triad of short stature, small ears, and small and/or absent patellae with variable expressivity. We report on the identification of a homozygous deleterious mutation in the ORC6 gene in previously described fetuses at the severe end ...
Stavit Allon, Shalev +3 more
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Mutations in genes encoding the origin recognition complex subunits cause Meier–Gorlin syndrome. The disease manifests a triad of short stature, small ears, and small and/or absent patellae with variable expressivity. We report on the identification of a homozygous deleterious mutation in the ORC6 gene in previously described fetuses at the severe end ...
Stavit Allon, Shalev +3 more
openaire +2 more sources
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2017
To identify the genetic cause for a 11-year-old Chinese boy with Meier-Gorlin syndrome (MGS).Chromosomal microarray analysis (CMA) was used to detect potential variations, while whole exome sequencing (WES) was used to identify sequence variants. Sanger sequencing was used to confirm the suspected variants.The boy has featured short stature, microtia ...
Juan, Li +7 more
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To identify the genetic cause for a 11-year-old Chinese boy with Meier-Gorlin syndrome (MGS).Chromosomal microarray analysis (CMA) was used to detect potential variations, while whole exome sequencing (WES) was used to identify sequence variants. Sanger sequencing was used to confirm the suspected variants.The boy has featured short stature, microtia ...
Juan, Li +7 more
openaire +1 more source