Results 51 to 60 of about 1,309 (131)
Advanced Science, Volume 12, Issue 35, September 18, 2025.To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu +13 more
wiley +1 more source
The Plant Journal, Volume 123, Issue 3, August 2025.Significance Statement Plants regulate cell division to adapt growth to environmental changes. In Arabidopsis thaliana, AIP10 acts as a hub linking the cell cycle to primary metabolism. Its silencing increases cell division rates, enhances carbon fixation, and boosts metabolite accumulation, driving improved development and productivity. SUMMARY Plants
Patrícia Montessoro +19 more
wiley +1 more source
Role of the Orc6 Protein in Origin Recognition Complex-Dependent DNA Binding and Replication in Drosophila melanogaster [PDF]
Molecular and Cellular Biology, 2007 The six-subunit origin recognition complex (ORC) is a DNA replication initiator protein in eukaryotes that defines the localization of the origins of replication. We report here that the smallest Drosophila ORC subunit, Orc6, is a DNA binding protein that is necessary for the DNA binding and DNA replication functions of ORC.
Maxim, Balasov +2 more
openaire +2 more sources
Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing
BioEssays, Volume 47, Issue 7, July 2025.Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck +1 more
wiley +1 more source
Drosophila model of Meier‐Gorlin syndrome based on the mutation in a conserved C‐Terminal domain of Orc6 [PDF]
American Journal of Medical Genetics Part A, 2015 Meier‐Gorlin syndrome (MGS) is an autosomal recessive disorder characterized by microtia, primordial dwarfism, small ears, and skeletal abnormalities. Patients with MGS often carry mutations in the genes encoding the components of the pre‐replicative complex such as Origin Recognition Complex (ORC) subunits Orc1, Orc4, Orc6, and helicase loaders Cdt1 ...
Maxim, Balasov +2 more
openaire +2 more sources
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study elucidates the mechanism underlying LINC01235 promotes clonal evolution and selection under treatment pressure by facilitating DNA replication licensing and CIN, leading to increased therapeutic resistance in HER2+ breast cancer. Targeting LINC01235‐related pathways with ATR inhibitors may be a viable strategy for clinical application ...
Qi Zhang +18 more
wiley +1 more source
A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity [PDF]
Proceedings of the National Academy of Sciences, 2003 Coordination between separate pathways may be facilitated by the requirements for common protein factors, a finding congruent with the link between proteins regulating DNA replication with other important cellular processes. We report that the smallest of Drosophila origin recognition ...
Igor N, Chesnokov +2 more
openaire +2 more sources
The Application of Clinical Genetics, 2022 Viktoriia Zabnenkova,1 Olga Shchagina,1 Olga Makienko,2 Galina Matyushchenko,2 Oxana Ryzhkova1 1Molecular Genetics Laboratory № 3 The Shared Resource Centre “Genome”, Federal State Budgetary Scientific Institution Research Centre for Medical ...
Zabnenkova V +4 more
doaj
Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.ABSTRACT Osteosarcoma (OS) is the most frequent primary solid malignancy of bone, whose course is usually dismal without efficient treatments. The aim of the study was to discover novel risk models to more accurately predict and improve the prognosis of patients with osteosarcoma.
Yukang Que +8 more
wiley +1 more source
A Novel Deer Antler‐Inspired Bone Graft Triggers Rapid Bone Regeneration
Advanced Materials, Volume 37, Issue 6, February 12, 2025.Inspired by the rapid regeneration of antlers, HAMA hydrogel as a carrier for incorporating EVsABPCs into antler‐DCB is utilized. Notably, the antler‐DCB@EVsABPCs showed a strong ability to recruit endogenous BMSCs and transformed them an ABPC‐like cells, thereby facilitating rapid bone formation.
Shengyou Li +21 more
wiley +1 more source