Results 31 to 40 of about 1,309 (131)

ORC6 acts as a biomarker and reflects poor outcome in clear cell renal cell carcinoma

Journal of Cancer, 2022
Purpose: To explore the role of ORC6 in clear cell renal cell carcinoma (ccRCC). Methods: The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database was used to investigate the association between ORC6 expression and clinicopathological parameters.
Pan, Qiufeng, Li, Fuchun, Ding, Yi, Huang, Haoxuan, Guo, Ju   +4 more
openaire   +2 more sources

Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast. [PDF]

PLoS Genetics, 2017
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5).
Joseph C Sanchez, Elizabeth X Kwan, Thomas J Pohl, Haley M Amemiya, M K Raghuraman, Bonita J Brewer   +5 more
doaj   +1 more source

Integrative Analysis of MicroRNA and Gene Interactions for Revealing Candidate Signatures in Prostate Cancer

Frontiers in Genetics, 2020
MicroRNA (miRNA)–gene interactions are well-recognized as involved in the progression of almost all cancer types including prostate cancer, which is one of the most common cancers in men.
Jingchao Wei, Yinghao Yin, Qiancheng Deng, Jun Zhou, Yong Wang, Guangming Yin, Jianfu Yang, Yuxin Tang   +7 more
doaj   +1 more source

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

eLife, 2013
In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan, James M Berger   +5 more
doaj   +1 more source

Humanized Drosophila model of the Meier-Gorlin syndrome reveals conserved and divergent features of the Orc6 protein [PDF]

Genetics, 2020
Abstract Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder characterized by microtia, primordial dwarfism, small ears and skeletal abnormalities. Patients with MGS often carry mutations in the genes encoding the subunits of the Origin Recognition Complex (ORC), components of the pre-replicative ...
Balasov, Maxim, Akhmetova, Katarina, Chesnokov, Igor   +2 more
openaire   +3 more sources

Functional insight into the role of Orc6 in septin complex filament formation inDrosophila

Molecular Biology of the Cell, 2015
Septins belong to a family of polymerizing GTP-binding proteins that are important for cytokinesis and other processes that involve spatial organization of the cell cortex. We reconstituted a recombinant Drosophila septin complex and compared activities of the wild-type and several mutant septin complex variants both in vitro and in vivo.
Akhmetova, Katarina, Balasov, Maxim, Huijbregts, Richard P. H., Chesnokov, Igor   +3 more
openaire   +2 more sources

Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability

G3: Genes, Genomes, Genetics, 2018
Septin proteins are polymerizing GTPases that are found in most eukaryotic species. Septins are important for cytokinesis and participate in many processes involving spatial modifications of the cell cortex. In Drosophila, septin proteins Pnut, Sep1, and
Katarina Akhmetova, Maxim Balasov, Anton Svitin, Elena Chesnokova, Matthew Renfrow, Igor Chesnokov   +5 more
doaj   +1 more source

DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in Mice

Advanced Science, 2020
Post‐translational modification of proteins by N‐linked glycosylation is crucial for many life processes. However, the exact contribution of N‐glycosylation to mammalian female reproduction remains largely undefined.
Hui Li, Liji You, Yufeng Tian, Jing Guo, Xianbao Fang, Chenmin Zhou, Lanying Shi, You‐Qiang Su   +7 more
doaj   +1 more source

Biomarker Discovery for the Carcinogenic Heterogeneity Between Colon and Rectal Cancers Based on lncRNA-Associated ceRNA Network Analysis

Frontiers in Oncology, 2020
BackgroundColorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Emerging evidence has revealed that risk factors and metastatic patterns differ greatly between colon and rectal cancers.
Xin Qi, Xin Qi, Yuxin Lin, Yuxin Lin, Xingyun Liu, Xingyun Liu, Jiajia Chen, Bairong Shen   +7 more
doaj   +1 more source

ORC6 marks a replication-active malignant epithelial state and is associated with immune-low features in oral squamous cell carcinoma

Frontiers in Oncology
IntroductionOral squamous cell carcinoma (OSCC) shows marked biological heterogeneity, but markers that connect malignant epithelial states with the tumor immune context remain limited.
Shaofu Yan, Shaofu Yan, Shaofu Yan, Wenqi Tan, Wenqi Tan, Wenqi Tan, Yanxin Zhang, Jinyan Si, Jinyan Si, Jiehua Guo, Jiehua Guo, Jiehua Guo, Bo Yang, Bo Yang, Bo Yang, Jing Shi, Jing Shi, Jing Shi   +17 more
doaj   +1 more source