Results 21 to 30 of about 1,309 (131)

Functional analysis of an Orc6 mutant in Drosophila [PDF]

Proceedings of the National Academy of Sciences, 2009
The origin recognition complex (ORC) is a 6-subunit complex required for the initiation of DNA replication in eukaryotic organisms. ORC is also involved in other cell functions. The smallest Drosophila ORC subunit, Orc6, is important for both DNA replication and cytokinesis. To study the role
Maxim, Balasov, Richard P H, Huijbregts, Igor, Chesnokov   +2 more
openaire   +2 more sources

An 11-Year-Old Girl With Rare Diagnosis of Meier-Gorlin Syndrome Accompanied by Neonatal Seizure, Mental Retardation, and Attention Deficit Hyperactivity Disorder: A Case Report and Review of Literature

Acta Medica Iranica, 2022
Meier-Gorlin syndrome (MGS) is a rare autosomal recessive disorder with homozygous or heterozygous mutations in one of the five following genes (ORC1, ORC4, ORC6, CDT1, and CDC6).
Shahin Koomanaee, Setila Dalili, Seyyedeh Azade Hoseini Nouri, Seyedeh Zohreh Jalali, Manijeh Tabrizi, Ghazaleh Aldaghi, Afagh Hassanzadeh Rad   +6 more
doaj   +1 more source

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance

Cancer Medicine, 2023
Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma (LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5, and ORC6 form a replication–initiator complex to ...
Min Tang, Juan Chen, Tian Zeng, Dong‐mei Ye, Yu‐kun Li, Juan Zou, Yu‐ping Zhang   +6 more
doaj   +1 more source

Curcumol overcomes cisplatin resistance and rewires glycolysis-H3K9la-ORC6 axis to trigger ferroptosis in bladder cancer. [PDF]

Chin J Cancer Res
Cisplatin-based chemotherapy is a cornerstone for bladder cancer treatment, but the development of resistance remains a major clinical challenge. Curcumol, a bioactive sesquiterpenoid derived from Curcumae Rhizoma, has shown anti-tumor potential. This study investigated the efficacy of curcumol in overcoming cisplatin resistance and elucidated its ...
Zhang F, Yang Y, Zhang R, Hu H, Zhou C, Wang J, Wu R, Li E, Cho WC, Zhang D, Zhang Q, Feng D.   +11 more
europepmc   +3 more sources

CDK prevents Mcm2–7 helicase loading by inhibiting Cdt1 interaction with Orc6 [PDF]

Genes & Development, 2011
In Saccharomyces cerevisiae cells, B-type cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits, Orc2 and Orc6, to inhibit helicase loading. We show that helicase loading by ORC is inhibited by two distinct CDK-dependent mechanisms.
Shuyan, Chen, Stephen P, Bell
openaire   +2 more sources

Transcriptome Analysis of the Anti-Proliferative Effects of Ginsenoside Rh3 on HCT116 Colorectal Cancer Cells

Molecules, 2022
The mechanism of ginsenoside Rh3 activity against cancer remains unclear. This study aimed to investigate the underlying mechanism. The effects of Rh3 on the cell proliferation, migration and invasion, and cycle and apoptosis were analyzed using CCK-8 ...
Siying Teng, Xi Lei, Xinmin Zhang, Dongming Shen, Qiuyi Liu, Yingjie Sun, Yi Wang, Zhongyi Cong   +7 more
doaj   +1 more source

Drosophila Orc6 Facilitates GTPase Activity and Filament Formation of the Septin Complex [PDF]

Molecular Biology of the Cell, 2009
The origin recognition complex or ORC is a six-subunit protein important for DNA replication and other cell functions. Orc6, the smallest subunit of ORC, is essential for both replication and cytokinesis in Drosophila, and interacts with the septin protein Pnut, which is part of the Drosophila septin complex. In this study, we describe the analysis of
Richard P H, Huijbregts, Anton, Svitin, Monica W, Stinnett, Matthew B, Renfrow, Igor, Chesnokov   +4 more
openaire   +2 more sources

An essential role for Orc6 in DNA replication through maintenance of pre‐replicative complexes [PDF]

The EMBO Journal, 2006
The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G(1) phase assembly of pre-replicative complexes (pre-RC). Only the Orc1-5 subunits appear to be required for origin binding in budding yeast, yet Orc6 is an essential protein for cell proliferation.
Jeffrey W, Semple, Lance F, Da-Silva, Eric J, Jervis, Jennifer, Ah-Kee, Hyder, Al-Attar, Lutz, Kummer, John J, Heikkila, Philippe, Pasero, Bernard P, Duncker   +8 more
openaire   +2 more sources

Multiple functions of the Drosophila Orc6 protein

The FASEB Journal, 2009
The Origin recognition complex (ORC) is important for the DNA replication in eukaryotic cells. ORC is also involved in other cell functions. The smallest Drosophila ORC subunit, Orc6, consists of two functional domains. Larger N‐terminal domain directly involved in DNA binding and is important for ORC‐dependent
Igor Chesnokov, Maxim Balasov, Richard Huijbregts, Anton Svitin   +3 more
openaire   +1 more source

Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB [PDF]

Proceedings of the National Academy of Sciences, 2011
The Origin Recognition Complex (ORC) is a six-subunit protein important for the initiation of DNA replication in eukaryotic cells. Orc6 is the smallest and the least conserved among ORC subunits. It is required for the DNA replication but also has a function in cytokinesis in metazoan species, however, the mechanisms of Orc6 action in these processes ...
Shixuan, Liu, Maxim, Balasov, Hongfei, Wang, Lijie, Wu, Igor N, Chesnokov, Yingfang, Liu   +5 more
openaire   +2 more sources