Results 11 to 20 of about 1,309 (131)

Phosphorylation of Orc6 During Mitosis Regulates DNA Replication and Ribosome Biogenesis [PDF]

Molecular and Cellular Biology
The human Origin Recognition Complex (ORC) is required not only for the initiation of DNA replication, but is also implicated in diverse cellular functions, including chromatin organization, centrosome biology, and cytokinesis. The smallest subunit of ORC, Orc6, is poorly conserved amongst eukaryotes.
Supriya Prasanth, Kannanganattu Prasanth, Yo-Chuen Lin   +2 more
exaly   +4 more sources

DNA Damage-Induced, S-Phase Specific Phosphorylation of Orc6 is Critical for the Maintenance of Genome Stability [PDF]

Molecular and Cellular Biology, 2023
The smallest subunit of the human Origin Recognition Complex, hOrc6, is required for DNA replication progression and plays an important role in mismatch repair (MMR) during S-phase. However, the molecular details of how hOrc6 regulates DNA replication and DNA damage response remain to be elucidated.
Supriya Prasanth, Yo-Chuen Lin, Virgilia Macias   +2 more
exaly   +4 more sources

Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]

Cell Communication and Signaling
Lipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie, Haisu Lu, Jiayi Zheng, Jianfeng Song, Keyu Sun   +4 more
doaj   +2 more sources

Origin recognition complex 6 overexpression promotes growth of glioma cells [PDF]

Cell Death and Disease
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma.
Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu   +5 more
doaj   +2 more sources

Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]

Cell Death and Disease
Exploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang, Chun-ying Luo, Bing-tao Huang, Siyang Wu, Jian Shu, Chang-gong Lan, Fuquan Zhang   +6 more
doaj   +2 more sources

Clinical potential and experimental validation of prognostic genes in hepatocellular carcinoma revealed by risk modeling utilizing single cell and transcriptome constructs [PDF]

Frontiers in Immunology
BackgroundHepatocellular carcinoma (HCC) is the leading cause of tumor-related mortality worldwide. There is an urgent need for predictive biomarkers to guide treatment decisions.
Hang Deng, Xu Wang, Zi-Ang Jiang, Jian Xu, Yu Zhang, Yao Zhou, Jun Gong, Xiang-Yu Lu, Yi-Fu Hou, Hao Zhang   +9 more
doaj   +2 more sources

scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling [PDF]

Asian Journal of Andrology
The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining spermatogenesis. The single-cell RNA sequencing (scRNA-seq) analysis of the testis was performed to identify genes upregulated in spermatogonia.
Shi-Wei Liu, Jia-Qiang Luo, Liang-Yu Zhao, Ning-Jing Ou, Chao-Yang, Yu-Xiang Zhang, Hao-Wei Bai, Hong-Fang Sun, Jian-Xiong Zhang, Chen-Cheng Yao, Peng Li, Ru-Hui Tian, Zheng Li, Zi-Jue Zhu   +13 more
doaj   +2 more sources

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics [PDF]

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +2 more sources

An Orc6 tether mediates ORC binding-site switching during replication origin licensing. [PDF]

Proc Natl Acad Sci U S A
Abstract During origin licensing, the origin recognition complex (ORC) loads two Mcm2-7 helicases onto DNA in a head-to-head conformation, establishing the foundation for subsequent bidirectional replication. Single-molecule experiments support a helicase-loading model in which one ORC loads both Mcm2-7 helicases at origins. For this to
Driscoll D, Friedman LJ, Gelles J, Bell SP.   +3 more
europepmc   +4 more sources

Orc6 at replication fork enables efficient mismatch repair [PDF]

, 2021
Abstract In eukaryotes, the Origin Recognition Complex (ORC) is required for the initiation of DNA replication. The smallest subunit of ORC, Orc6, is essential for pre-replication complex (pre-RC) assembly and cell viability in yeast and for cytokinesis in metazoans.
Yo-Chuen Lin, Arindam Chakraborty, Dazhen Liu, Jaba Mitra, Lyudmila Y Kadyrova, Rosaline Y.C. Hsu, Mariam K. Arif, Sneha Adusumilli, Taekjip Ha, Farid A Kadyrov, Kannanganattu V. Prasanth, Supriya G. Prasanth   +11 more
openaire   +1 more source