Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage [PDF]
Advanced ScienceCoordinating transcription and replication via transcription factors (TFs) is a conserved mechanism in higher eukaryotes. The role of TFs in regulating these processes in cancers remains unclear.
Jiaxi Zhang +14 more
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High ORC6 expression is a prognostic indicator of poor survival in glioma patients [PDF]
Scientific ReportsPrecision therapy for glioma remains a major challenge due to tumor heterogeneity. The Origin Recognition Complex Subunit 6 (ORC6) is a crucial regulator of DNA replication initiation.
Jin Feng, Wang Mengjie
exaly +3 more sources
Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression [PDF]
Frontiers in Immunology, 2023 BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division.
Jinfeng Zhu +23 more
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ORC6 drives the malignant progression of cervical squamous intraepithelial lesions and serves as a biomarker for high-grade dysplasia [PDF]
Frontiers in OncologyBackgroundOrigin Recognition Complex Subunit 6 (ORC6) is essential for DNA replication initiation. However, its dynamic expression patterns and potential biological functions during the progression of cervical lesions remain unclear.MethodsWe analyzed ...
Rouyi Chen +7 more
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Machine learning derived ORC6 as a hub biomarker for predicting tumor microenvironment, prognoses, and therapeutic responses in lung adenocarcinoma [PDF]
Translational OncologyThe origin recognition complex (ORC) is a DNA-binding complex composed of six subunits involved in DNA replication in cancer cells. The prognostic and immunological implications of ORC6 in lung adenocarcinoma (LUAD) are not yet clear. This study utilizes
Xin Huang +6 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 BackgroundIn recent years, microRNA-1-3p (miR-1-3p) has been linked to the progression of multiple cancers, whereas little is known about its role in hepatocellular carcinoma (HCC).
Hu Chen, Dongde Wu, Hu Jianhua
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Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin [PDF]
PLoS ONE, 2008 Previous studies from our group have shown that the expression levels of Orc6 were highly elevated in colorectal cancer patient specimens and the induction of Orc6 was associated with 5-fluorouracil (5-FU) treatment.
Jingfang Ju, Yaguang Xi
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License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]
BioessaysOrigin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Frisbie V, Bleichert F.
europepmc +2 more sources
AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms [PDF]
The EMBO JournalDNA replication initiation is a tightly regulated process that requires the coordinated assembly of replication machineries throughout the genome. During the first step of initiation, origin licensing, the MCM replicative helicase motor is loaded onto ...
Olivia Hunker, Franziska Bleichert
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ORC6, a novel prognostic biomarker, correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis [PDF]
BMC Cancer, 2023 Background The origin recognition complex (ORC), a six-subunit DNA-binding complex, participates in DNA replication in cancer cells. Specifically in prostate cancers, ORC participates the androgen receptor (AR) regulated genomic amplification and tumor ...
Yuan Lin +9 more
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