Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
A hierarchical navigation decision-making method for UAV swarms in unknown communication-constrained environments. [PDF]
PLoS OneXiong H, Yu B, Zhang J, Dong H.
europepmc +1 more source
KIF1A‐Mediated Axonal Transport of Netrin‐1 in iPSC‐Derived Human Forebrain Neurons
Cytoskeleton, EarlyView.ABSTRACT Netrin‐1 is a secreted laminin‐like protein that functions as a guidance cue for axon pathfinding in development. Netrin‐1 also modulates synapse formation in developing neurons and long‐term potentiation in mature neurons. Netrin‐1 is expressed in human neurons; however, its intracellular distribution and trafficking have not been assessed ...
T. Y. Leung +5 more
wiley +1 more source
Development and Preliminary Validation of ORCA-PD, an Online Rapid Cognitive Assessment for Parkinson Disease: Mixed Methods Study. [PDF]
J Med Internet ResLithwick Algon A +3 more
europepmc +1 more source
Embryonic development of the Mediterranean starfish Hacelia attenuata
Developmental Dynamics, EarlyView.Abstract Background Starfish play essential ecological roles as predators and ecosystem regulators; however, detailed developmental descriptions exist for only a handful of species, none of which are from the Mediterranean Sea. Results In this study, we provide the first full account of the development of the Mediterranean starfish Hacelia attenuata ...
Silvia Caballero‐Mancebo +3 more
wiley +1 more source
Low-Temperature xTB-MD-DFT Screening of Functionalized Oxide Surface-Patch Models (TiO<sub>2</sub>, ZnO, CeO<sub>2</sub>) for Hydrocarbon Association and Microbial-Proxy Perturbation Assessment in Cold Bioremediation. [PDF]
Nanomaterials (Basel)Guerra J +4 more
europepmc +1 more source
Developmental Dynamics, EarlyView.Abstract Understanding the dynamic nature of developmental networks requires live imaging techniques capable of capturing real‐time developmental processes in wild‐type and mutant embryos as they are exposed to pharmacological perturbations. A peculiar developmental patterning process in early vertebrate embryos is the sequential segmentation of ...
Mohammed Nakhuda, M. Fethullah Simsek
wiley +1 more source
Glycerol‐Modified Biphasic Silicone Gel for Synergistic Thermal Transport and Dielectric Reliability
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.A surfactant‐free glycerol‐modified biphasic silicone gel establishes metastable liquid interfaces that simultaneously enhance phonon transport and induce deep traps (1.28 eV), enabling synergistic electrothermal performance of enhanced thermal conductivity (+33.3%), thermal diffusivity (+48.3%), and DC breakdown strength (+57.6%) with suppressed space
Xinyue Zhang +3 more
wiley +1 more source
β‐Hydroxybutyrate reduces neuronal excitability via GIRK channels
Epilepsia, EarlyView.β‐Hydroxybutyrate decreases neuronal excitability by activating GIRK channels through HCAR2 signaling, providing a cellular mechanism that may contribute to the antiseizure effects of the ketogenic diet. Abstract Objective The ketogenic diet is used to treat drug‐resistant epilepsy, yet the molecular mechanisms coupling metabolic state to seizure ...
Soudabeh Naderi +8 more
wiley +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt +7 more
wiley +1 more source