Artemisinic Acid Serves as a Novel Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Cambial Meristematic Cells [PDF]
Natural Product Communications, 2016 To investigate the effect of artemisinic acid (AA) on improving the production of terpenoid indole alkaloids (TIAs) of Catharanthus roseus cambial meristematic cells (CMCs), feeding AA to C.
Mingxuan Wang +6 more
doaj +3 more sources
Metabolomics in plants and humans: Applications in the prevention and diagnosis of diseases. [PDF]
BioMed Research International, Volume 2013, Issue 1, 2013., 2013 In the recent years, there has been an increase in the number of metabolomic approaches used, in parallel with proteomic and functional genomic studies. The wide variety of chemical types of metabolites available has also accelerated the use of different
Busi, María Victoria +2 more
core +5 more sources
Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes. [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Li CY, Gibson SI.
europepmc +3 more sources
Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense. [PDF]
FEBS Open Bio, 2022 An AP2/ERF transcription factor, BcERF3, was identified in an important medicinal plant, Bupleurum chinense. It is dominantly expressed in the root, where it localizes in cell nuclei and is inducible by MeJA. Overexpression of BcERF3 in B. chinense hairy roots caused increased biosynthesis of saikosaponin a, c, and d, accompanied by elevated gene ...
Han W +8 more
europepmc +2 more sources
Cell-type-aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus. [PDF]
New PhytolSummary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the source of the anticancer compounds vinblastine and vincristine. In the leaf, the C.
Li C +8 more
europepmc +2 more sources
The Recruitment Model of Metabolic Evolution: Jasmonate-Responsive Transcription Factors and a Conceptual Model for the Evolution of Metabolic Pathways. [PDF]
Front Plant Sci, 2019 Plants produce a vast array of structurally diverse specialized metabolites with various biological activities, including medicinal alkaloids and terpenoids, from relatively simple precursors through a series of enzymatic steps.
Shoji T.
europepmc +3 more sources
Metabolomics analysis reveals both plant variety and choice of hormone treatment modulate vinca alkaloid production in Catharanthus roseus. [PDF]
Plant Direct, 2020 Abstract The medicinal plant Catharanthus roseus produces numerous secondary metabolites of interest for the treatment of many diseases – most notably for the terpene indole alkaloid (TIA) vinblastine, which is used in the treatment of leukemia and Hodgkin's lymphoma.
Fraser VN, Philmus B, Megraw M.
europepmc +2 more sources
Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging [PDF]
ACS Nano, 2018 Hung V-T Nguyen +2 more
exaly +2 more sources
Nano‐enabled stress‐smart agriculture: Can nanotechnology deliver drought and salinity‐smart crops?
Journal of Sustainable Agriculture and Environment, Volume 2, Issue 3, Page 189-214, September 2023., 2023 Salinity and drought stress substantially decrease crop yield and superiority, threatening the world's food security. Nanotechnology holds great potential for designing stress‐smart, sustainable crops to feed the growing population. Abstract Salinity and drought stress substantially decrease crop yield and superiority, directly threatening the food ...
Ali Raza +7 more
wiley +1 more source
New Phytologist, Volume 239, Issue 4, Page 1353-1367, August 2023., 2023 Summary Steroidal glycoalkaloids (SGAs) constitute a characteristic class of antinutritional metabolites that are found in certain Solanum species. Despite the considerable studies on SGA biosynthesis, the mechanisms of crosstalk between hormone signaling pathways that regulate SGA content still remain to be elucidated.
Yingchen Hao +8 more
wiley +1 more source