Results 151 to 160 of about 56,843 (293)

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Aggregating geo-processing services in a bomb threat scenario

, 2008
. The aggregation of web services in order to achieve a common goal is a basic concept in Service Oriented Architectures (SOA). This paper demonstrates OGC Web Services (OWS) aggregation based on a simulated bomb threat scenario which is a possible ...
Beate Stollberg, Service Orchestration, Er Zipf   +2 more
core  

Laurent Coq / Walter Smith III, The Lafayette Suite.

Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2016
Ludovic Florin
doaj  

Rethinking cholera response: an orchestration framework for future preparedness in fragile conflict-affected settings, a case study from Sudan, 2025. [PDF]

Front Public Health
Ayyad FA, Izzoddeen A, Elbukhari Ibrahim M, Awadalla H.   +3 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Orchestrating agentic systems at ALS beamline 5.3.1 with Osprey and Bluesky. [PDF]

J Synchrotron Radiat
Chan KH, Ha Y, Islegen-Wojdyla A, Leon S, Garces M, McReynolds D, Chong X, Sriramoju RV, Mahl J, Guenzing D, Koepp W, Hexemer A, Hellert T, Chavez T.   +13 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Service-Based RAN User Plane Decoupling and Orchestration via ComBERT for AI AgentServices. [PDF]

Sensors (Basel)
Ding H, Du S, Sun X, Guo X, Yuan C, Tian L, Zhang S, Jin J.   +7 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Fedflow: cloud orchestration for federated learning with the FeatureCloud platform. [PDF]

Bioinform Adv
Weilguny L, Probul N, Ren Y, Pons N, Baumbach J, Almeida M.   +5 more
europepmc   +1 more source