Results 81 to 90 of about 56,843 (293)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Integrated thinking, orchestration of the six capitals and value creation
, 2021 Purpose: This paper aims to explore how the integrated thinking of a chief executive officer (CEO) impacts the management’s orchestration of the six capitals to create value in an organization.
Senaratne, S, Herath, R, Gunarathne, N
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Insights Into the Musical Dramaturgy of Astor Piazzolla’s Operita Maria de Buenos Aires
Studia Universitatis Babeş-Bolyai. MusicaNumerous pages have already been filled out about Astor Piazzolla’s operita Maria de Buenos Aires. What I aim to bring anew through this work is the delineation of the musical dramaturgy within this work, with an emphasis on the orchestral ensemble ...
Gina-Mihaela PAVEL
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
ComputersThe shift from traditional monolithic architectures to container-based solutions has revolutionized application deployment by enabling consistent, isolated environments across various platforms.
Bruno Nascimento +4 more
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
3-Level Behavioural Models for Semantic Web Services [PDF]
, 2008 There are two types of behavioural model in the WSMO semantic description of services: an orchestration and a choreography, together called the interface.
HENOCQUE, Laurent +3 more
core
Orchestration of Robotic Activities in Classrooms: Challenges and Opportunities [PDF]
, 2019 Bringing robots into classrooms presents a new set of challenges for classroom management and teacher support compared to traditional technology-enhanced learning and has been left almost unexplored by the research community.
Olsen, Jennifer K. +14 more
core +4 more sources
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source