Results 61 to 70 of about 59,128 (285)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
π-EconomyModels for assessing the level of digital maturity are widely used as a tool for justifying decisions on the development of organizations. Similar models exist in the field of assessing the maturity of ecosystems.
Gileva Tatiana
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Evaluation of GenAI Capabilities to Implement Professional Tasks
Foresight and STI GovernanceGenerative AI (GenAI) or large language models (LLMs) have been running the world since 2022, but despite all the trends surrounding the use of generative models, these cannot yet be used professionally.
Yaroslav Kouzminov +1 more
doaj +1 more source
Connected Health Innovation: Data Access Challenges in the Interface of AI Companies and Hospitals
Technology Innovation Management Review, 2019 The purpose of this paper is to explore the challenges and potential solutions regarding data access for innovation in the realm of connected health. Theoretically, our study combines insights from data management and innovation network orchestration ...
Laura Kemppainen +3 more
doaj +1 more source
Beobachtungen zum Verhältnis von Form und Instrumentation am Beispiel des Menuetts aus W. A. Mozarts Sinfonie Nr. 40 in g-Moll KV 550 [PDF]
Zeitschrift der Gesellschaft für Musiktheorie, 2014 Der folgende Aufsatz untersucht die enge Wechselbeziehung zwischen Satztechnik, übergeordnetem Formaufbau und instrumentatorischen Entscheidungen im Menuett, dem 3. Satz aus Mozarts Sinfonie KV 550.
Emmanouil Vlitakis
doaj +1 more source