Results 41 to 50 of about 3,046,845 (266)

Strong Stability Preserving Two-Derivative Two-Step Runge-Kutta Methods

Mathematics
In this study, we introduce the explicit strong stability preserving (SSP) two-derivative two-step Runge-Kutta (TDTSRK) methods. We propose the order conditions using Albrecht’s approach, comparing to the order conditions expressed in terms of rooted ...
Xueyu Qin, Zhenhua Jiang, Chao Yan
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Necessary and Sufficient Second-Order Optimality Conditions on Hadamard Manifolds

Mathematics, 2020
This work is intended to lead a study of necessary and sufficient optimality conditions for scalar optimization problems on Hadamard manifolds. In the context of this geometry, we obtain and present new function types characterized by the property of ...
Gabriel Ruiz-Garzón, Jaime Ruiz-Zapatero, Rafaela Osuna-Gómez, Antonio Rufián-Lizana   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

New Oscillation Conditions for Second Order Half-Linear Advanced Difference Equations [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
This paper aims to establish adequate conditions that are intended for the oscillation of every solution of the second order advanced type half-linear difference equations with noncanonical form.
P. Dinakar, S. Selvarangam, E. Thandapani   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Nonresonance conditions for fourth order nonlinear boundary value problems

International Journal of Mathematics and Mathematical Sciences, 1994
This paper is devoted to the study of the problemu(4)=f(t,u,u′,u″,u‴),u(0)=u(2π),   u′(0)=u′(2π),   u″(0)=u″(2π),   u‴(0)=u‴(2π).We assume that f can be written under the formf(t,u,u′,u″,u‴)=f2(t,u,u′,u″,u‴)u″+f1(t,u,u′,u″,u‴)u′+f0(t,u,u′,u″,u‴)u+r(t,u,u′
C. De Coster, C. Fabry, F. Munyamarere   +2 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source