Results 81 to 90 of about 3,046,845 (266)

Nonlinear Coupled Fractional Order Systems with Integro-Multistrip-Multipoint Boundary Conditions

International Journal of Analysis and Applications, 2019
We study the existence and uniqueness of solutions for a nonlinear system of coupled fractional differential equations equipped with nonlocal coupled integro-multistrip-multipoint boundary conditions.
Bashir Ahmad, Ahmed Alsaedi, Sotiris K. Ntouyas   +2 more
doaj   +2 more sources

Stability Conditions of Second Order Integrodifferential Equations with Variable Delay

Abstract and Applied Analysis, 2014
We investigate integrodifferential functional differential equations ẍ+f(t,x,ẋ)ẋ+∫t-r(t)t‍a(t,s)g(x(s))ds=0 with variable delay. By using the fixed point theory, we obtain conditions which ensure that the zero solution of this equation is stable under
Dingheng Pi
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Explicit solutions for a system of first-order partial differential equations-II

Electronic Journal of Differential Equations, 2011
In this note we give an explicit formula for the solution of conservative form of a system studied in a previous article [6], in the domain ${(x,t):x>0,t>0}$ with initial conditions at $t=0$ and with Bardos Leroux Nedelec boundary conditions at $x=0$.
Kayyunnapapra Thomas Joseph, Manas Ranjan Sahoo   +1 more
doaj  

Nullspace of the m-th order discrete problem with nonlocal conditions

Lietuvos Matematikos Rinkinys, 2016
In this paper, we obtain the representation of the nullspace for m-th order discrete linear problems with nonlocal conditions. An example is given. The research was partially supported by the Research Council of Lithuania (grant No. MIP-047/2014).
Gailė Paukštaitė, Artūras Štikonas
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Sufficient conditions for meromorphic starlikeness and close-to-convexity of order α

International Journal of Mathematics and Mathematical Sciences, 2001
The object of the present paper is to derive a property of certain meromorphic functions in the punctured unit disk. Our main theorem contains certain sufficient conditions for starlikeness and close-to-convexity of order α of meromorphic functions.
Nak Eun Cho, Shigeyoshi Owa
doaj   +1 more source