Results 81 to 90 of about 2,173,914 (285)
Contextual Approximation and Higher-Order Procedures [PDF]
, 2016 We investigate the complexity of deciding contextual approximation (refinement) in finitary Idealized Algol, a prototypical language combining higher-order types with state. Earlier work in the area established the borderline between decidable and undecidable cases, and focussed on the complexity of deciding approximation between terms in normal form ...
Ranko Lazic 0001, Andrzej S. Murawski
openaire +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A logarithmic approximation of linearly ordered colourings
CoRRA linearly ordered (LO) $k$-colouring of a hypergraph assigns to each vertex a colour from the set $\{0,1,\ldots,k-1\}$ in such a way that each hyperedge has a unique maximum element. Barto, Batistelli, and Berg conjectured that it is NP-hard to find an LO $k$-colouring of an LO 2-colourable 3-uniform hypergraph for any constant $k\geq 2$ [STACS'21 ...
Håstad, J +3 more
openaire +6 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2018 This paper studies the convergence of empirical measures of a stochastic approximation toward the invariant distribution of a Feller process. In particular, we provide a general and abstract approach to establish Central Limit Theorems (CLT) with given ...
Pagès, Gilles, Rey, Clément
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Second-Order Approximation of Dynamic Models with Time-Varying Risk [PDF]
This paper provides first and second-order approximation methods for the solution of nonlinear dynamic stochastic models in which the exogenous state variables follow conditionally-linear stochastic processes displaying time-varying risk. The first-order
Gianluca Benigno +2 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Order Barrier for Strong Approximation of Rough Volatility Models
, 2016 We study the strong approximation of a rough volatility model, in which the log-volatility is given by a fractional Ornstein-Uhlenbeck process with Hurst parameter ...
Neuenkirch, Andreas, Shalaiko, Taras
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source