Results 91 to 100 of about 173,742,459 (298)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

The compact eighth-order of approximation difference schemes for fourth-order differential equation

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы
Local and nonlocal boundary value problems (LNBVPs) related to fourth-order differential equations (FODEs) were explored. To tackle these problems numerically, we introduce novel compact four-step difference schemes (DSs) that achieve eighth-order of ...
A. Ashyralyev, I.M. Ibrahim
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

[Letter from the Order of Canada, 12 January 1973]

open access: yes, 1973
A letter from the Order of Canada addressed to Mr. de Grandmaison and signed by Carl Lochnan, Director of Honors. The letter includes information about the Investiture of the Order held on April 11, 1973, at the Government House in ...
The Order of Canada
core  

A new method for the integer order approximation of fractional order models

open access: yes, 2015
This paper is concerned with the finite–dimensional approximation of a fractional–order system represented in state–space form. To this purpose, resort is made to the Oustaloup method for approximating a fractional–order integrator by a rational filter ...
Krajewski W., Viaro U., Viaro, U.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Linear stationary iterative methods for the force-based quasicontinuum approximation [PDF]

open access: yes, 2012
Force-based multiphysics coupling methods have become popular since they provide a simple and efficient coupling mechanism, avoiding the difficulties in formulating and implementing a consistent coupling energy.
Luskin, Mitchell Barry   +1 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Local approximation of DSGE models around the risky steady state [PDF]

open access: yes
A DSGE model takes the mathematical form of a system of nonlinear stochastic equations. Except in a very few cases, there is no analytical solution and economists are left using numerical methods in order to obtain approximated solutions.
Juillard Michel
core  

Approximation of entire functions of slow growth on compact sets [PDF]

open access: yes, 2009
summary:In the present paper, we study the polynomial approximation of entire functions of several complex variables. The characterizations of generalized order and generalized type of entire functions of slow growth have been obtained in terms of ...
Kumar, Susheel, Srivastava, G. S.
core   +1 more source

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