Results 51 to 60 of about 65,964 (245)

Quadratic regression analysis for gene discovery and pattern recognition for non-cyclic short time-course microarray experiments

BMC Bioinformatics, 2005
Background Cluster analyses are used to analyze microarray time-course data for gene discovery and pattern recognition. However, in general, these methods do not take advantage of the fact that time is a continuous variable, and existing clustering ...
Getchell Thomas V, Borders Aaron S, Tarima Sergey, Liu Hua, Getchell Marilyn L, Stromberg Arnold J   +5 more
doaj   +1 more source

Order-restricted inference for monotone trend alternatives in contingency tables

Computational Statistics & Data Analysis, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Department of Statistics, University of Florida, Gainesville, FL 32611-8545, USA ( host institution ), Agresti, Alan, Coull, Brent A.   +2 more
openaire   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Yield response of winter wheat cultivars to environments modeled by different variance-covariance structures in linear mixed models

Spanish Journal of Agricultural Research, 2016
The main objectives of multi-environmental trials (METs) are to assess cultivar adaptation patterns under different environmental conditions and to investigate genotype by environment (G×E) interactions.
Marcin Studnicki, Wiesław Mądry, Kinga Noras, Elżbieta Wójcik-Gront, Edward Gacek   +4 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Statistical resolution of ambiguous HLA typing data.

PLoS Computational Biology, 2008
High-resolution HLA typing plays a central role in many areas of immunology, such as in identifying immunogenetic risk factors for disease, in studying how the genomes of pathogens evolve in response to immune selection pressures, and also in vaccine ...
Jennifer Listgarten, Zabrina Brumme, Carl Kadie, Gao Xiaojiang, Bruce Walker, Mary Carrington, Philip Goulder, David Heckerman   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Towards real-time control of a CartPole system on a quantum computer

Machine Learning: Science and Technology
The application of quantum reinforcement learning to real-time control systems faces significant challenges regarding hardware latency, noise susceptibility, and learning convergence.
Nguyen Truong Thu Ngo, Väinö Mehtola, Jérôme Lenssen, Peiyong Wang, Francesco Cosco, Tien-Fu Lu, James Q Quach   +6 more
doaj   +1 more source

FACTORS INFLUENCING THE ADOPTION OF INTEGRATED SOIL FERTILITY MANAGEMENT TECHNOLOGIES BY SMALLHOLDER FARMERS IN NAMTUMBO DISTRICT, TANZANIA [PDF]

Big Data in Agriculture
Sub-Saharan African smallholder farmers face two challenges: low production and restricted funding for nutrient inputs. By combining the use of enhanced germplasm, prudent fertiliser use, and organic matter management tailored to the local farming ...
Hija Walad Mwatawala, Estherbella Martin Burian   +1 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source