Results 71 to 80 of about 94,120 (308)

Ordered Algebraic Structures : Hahn Fields, Convex Valuations, and Exponentials

, 2023
This habilitation thesis contains seven articles dedicated to the valuation and model theoretic study of ordered algebraic structures. It is divided into three parts, each consisting of those articles focussing on a particular class of structures: Hahn ...
Krapp, Lothar Sebastian
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ordered fields and ŁΠ1/2-algebras

, 2009
In this work we further explore the connection between ŁΠ1/ 2-algebras and ordered fields. We show that any two ŁΠ1/ 2-chains generate the same variety if and only if they are related to ordered fields that have the same universal theory. This will yield
Marchioni, Enrico
core   +1 more source

Double field theory at order α′ [PDF]

Journal of High Energy Physics, 2014
We investigate $α'$ corrections of bosonic strings in the framework of double field theory. The previously introduced "doubled $α'$-geometry" gives $α'$-deformed gauge transformations arising in the Green-Schwarz anomaly cancellation mechanism but does not apply to bosonic strings.
Hohm, Olaf, Zwiebach, Barton
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Boson Fields in Ordered Magnets

Acta Physica Polonica A, 2015
Spin wave theory of magnetism reveals two severe shortcomings. First, it considers non quantized classical spins and, second, the predicted temperature power functions for the thermal decrease of the magnetic order parameter hold asymptotically at T = 0 only.
Hoser, A., Köbler, U.
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stabilization of three-dimensional charge order in YBa2Cu3O6+x via epitaxial growth

Nature Communications, 2018
In many cuprates the high temperature superconducting state competes with a charge ordered phase that has been difficult to investigate in detail. Here the authors show three-dimensional charge order can be stabilized in YBCO films and studied without ...
M. Bluschke, A. Frano, E. Schierle, D. Putzky, F. Ghorbani, R. Ortiz, H. Suzuki, G. Christiani, G. Logvenov, E. Weschke, R. J. Birgeneau, E. H. da Silva Neto, M. Minola, S. Blanco-Canosa, B. Keimer   +14 more
doaj   +1 more source