Results 91 to 100 of about 86,839 (265)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the intermediate value theorem over a non-Archimedean field

open access: yesLe Matematiche, 2013
The paper investigates general properties of the power series over a non- Archimedean ordered field, extending to the set of algebraic power series the intermediate value theorem and Rolle's theorem and proving that  an algebraic series attains its ...
Luigi Corgnier   +2 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

EICHLER ORDERS, TREES AND REPRESENTATION FIELDS [PDF]

open access: yesInternational Journal of Number Theory, 2013
The spinor class field for a genus of orders of maximal rank in a quaternion algebra 𝔄 over a number field K is an abelian extension Σ/K provided with a distance function associating elements of the corresponding Galois group to pairs of orders in that genus.
openaire   +5 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Evidence of sp-d Exchange Interactions in CdSe Nanocrystals Doped with Mn, Fe and Co: Atomistic Tight-Binding Simulation

open access: yesNanomaterials
Exploiting the atomistic tight-binding theory with the sp-d exchange term, the electronic and magnetic characteristics of CdSe nanoparticles embedded with Mn, Fe and Co are determined as a function of external magnetic fields to realize the sp-d exchange
Pruet Kalasuwan, Worasak Sukkabot
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Irreducible many-body correlations in topologically ordered systems

open access: yesNew Journal of Physics, 2016
Topologically ordered systems exhibit large-scale correlation in their ground states, which may be characterized by quantities such as topological entanglement entropy.
Yang Liu, Bei Zeng, D L Zhou
doaj   +1 more source

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