Results 81 to 90 of about 849,966 (288)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stabilization of three-dimensional charge order in YBa2Cu3O6+x via epitaxial growth

Nature Communications, 2018
In many cuprates the high temperature superconducting state competes with a charge ordered phase that has been difficult to investigate in detail. Here the authors show three-dimensional charge order can be stabilized in YBCO films and studied without ...
M. Bluschke, A. Frano, E. Schierle, D. Putzky, F. Ghorbani, R. Ortiz, H. Suzuki, G. Christiani, G. Logvenov, E. Weschke, R. J. Birgeneau, E. H. da Silva Neto, M. Minola, S. Blanco-Canosa, B. Keimer   +14 more
doaj   +1 more source

Monte Carlo Studies of the Ordering of the Three-Dimensional Isotropic Heisenberg Spin Glass in Magnetic Fields

, 2001
Spin and chirality orderings of the three-dimensional Heisenberg spin glass under magnetic fields are studied by large-scale equilibrium Monte Carlo simulations.
Binder K., Bokil H., de Almeida J. R. L., de Cortenary N., Fischer K. H., Gabay M., Hukushima K., Hukushima K., Hukushima K., Kawamura H., Kawamura H., Kawamura H., Kawamura H., Kawamura H., Kawamura H., Kawashima N., Kenning G. G., Kotliar G., Marinari E., Marinari E., Matsubara F., Matsubara F., Morgownik A. F. J., Ogielski A. T., Olive J. A., Parisi G., Petit D., Sherrington D., Yoshino H.   +28 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Tailoring symmetry groups using external alternate fields

, 2003
Macroscopic systems with continuous symmetries subjected to oscillatory fields have phases and transitions that are qualitatively different from their equilibrium ones.
, Acharyya M., Das J., De Gennes P. G., Dhar D., Dhar D., I Junier, J Kurchan, Shender E. F., Simoni F., Tabiryan N. V., Thomas P. B., Thomas P. B., Villain J.   +13 more
core   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Recent advances and applications of human brain models

Frontiers in Neural Circuits
Recent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids.
Kaneyasu Nishimura, Hironobu Osaki, Kotaro Tezuka, Daisuke Nakashima, Shintaro Numata, Yoshito Masamizu   +5 more
doaj   +1 more source

Ordered magnetic fields around radio galaxies: evidence for interaction with the environment

, 2011
We present detailed imaging of Faraday rotation and depolarization for the radio galaxies 0206+35, 3C 270, 3C 353 and M 84, based on Very Large Array observations at multiple frequencies in the range 1365 to 8440 MHz.
A. H. Bridle, Baum, Bicknell, Blanton, Bower, Bower, Burn, Carilli, Carilli, Croston, Croston, Croston, D. Guidetti, de Vaucouleurs, Dreher, Dursi, Eilek, Enßlin, Fanaroff, Faraday, Ferrari, Finoguenov, Finoguenov, Finoguenov, Forman, Goodger, Govoni, Guidetti, Guidetti, Hansen, Iwasawa, Jetha, Kraft, L. Gregorini, Laing, Laing, Laing, McNamara, McNamara, Miller, Minter, Morganti, Murgia, Nulsen P., P. Parma, R. A. Laing, Simard-Normandin, Simonetti, Swain, Trager, Tribble, Trussoni, Vacca, Wilson, Worrall, Worrall, Worrall, Worrall   +57 more
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Time-integrated Polarization of Structured Jets in Gamma-Ray Burst Prompt Emission

The Astrophysical Journal
The structure of gamma-ray burst (GRB) jets remains one of the most significant open questions in high-energy astrophysics. Observations of events like GRB 170817A, associated with gravitational waves, and the exceptionally bright GRB 221009A suggest ...
Qiannan Mai, Hongbang Liu, Jiangchuan Tuo, Zuke Feng, Qian Zhong, Kangfa Cheng, Jirong Mao, Enwei Liang   +7 more
doaj   +1 more source