Results 121 to 130 of about 321,441 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Atomless Lattice-Ordered Groups

, 1994
We show the existence of atomless lattice-ordered groups which have doubly transitive representations. In so doing, we answer a question of M. Giraudet from 1981 [4].
A. M. W. Glass
core   +1 more source

On the orders of finite semisimple groups [PDF]

Proceedings Mathematical Sciences, 2005
It is a theorem of Artin, Tits et al. that a finite simple group is determined by its order, with the exception of the groups (A_3(2), A_2(4)) and (B_n(q), C_n(q)) for n > 2, q odd. We investigate the situation for finite semisimple groups of Lie type.
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Covalent Organic Framework with 3D Ordered Channel and Multi-Functional Groups Endows Zn Anode with Superior Stability

Nano-Micro Letters
Highlights A fluorinated zincophilic covalent organic framework (COF-S-F) with sulfonic acid group (-SO3H) is prepared on the surface of Zn anode, which promotes the desolvation of hydrated Zn ions and inhibits the side reactions.
Bin Li, Pengchao Ruan, Xieyu Xu, Zhangxing He, Xinyan Zhu, Liang Pan, Ziyu Peng, Yangyang Liu, Peng Zhou, Bingan Lu, Lei Dai, Jiang Zhou   +11 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

IR Spectroscopic Studies on Water Confined in an Isoreticular MOF Series–Influence of the Metal and Linker Functionality

Advanced Materials Interfaces
Mono‐ and bimetallic MOF‐74 samples with different ratios of Mg2+ and Ni2+ (9:1, 7:3, and 1:1), as well as Ni‐MOF‐74 analogs with different pore sizes and functionalities, were loaded with water through the exposure to a controlled relative humidity.
Tabea C. V. Haug, Frank Hoffmann, Merve N. Tasova, Roy Heffels, Michael Fröba   +4 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

On the order of groups of automorphisms [PDF]

Transactions of the American Mathematical Society, 1936
Birkhoff, Garrett, Hall, Philip
openaire   +2 more sources

Group Order Logic

2025 40th Annual ACM/IEEE Symposium on Logic in Computer Science (LICS)
We introduce an extension of fixed-point logic ($\mathsf{FP}$) with a group-order operator ($\mathsf{ord}$), that computes the size of a group generated by a definable set of permutations. This operation is a generalization of the rank operator ($\mathsf{rk}$). We show that $\mathsf{FP} + \mathsf{ord}$ constitutes a new candidate logic for the class of
openaire   +3 more sources